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Post-transcriptional regulation of gene expression in trypanosomes and leishmanias

被引：317
作者：
Clayton, Christine
Shapira, Michal
机构：
[1] Heidelberg Univ, Zentrum Mol Biol, D-69120 Heidelberg, Germany
[2] Ben Gurion Univ Negev, Dept Life Sci, IL-84105 Beer Sheva, Israel
来源：
MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 2007年 / 156卷 / 02期
基金：
英国惠康基金;
关键词：
trypanosoma; Leishmania; mRNA; degradation; translation;
D O I：
10.1016/j.molbiopara.2007.07.007
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Gene expression in Kinetoplastids is very unusual in that the open reading frames are arranged in long polycistronic arrays, monocistronic mRNAs being created by post-transcriptional processing. Thus the regulation of gene expression is post-transcriptional. We here discuss recent results concerning the enzymes required for mRNA degradation, and components of the translation initiation machinery, and how both are regulated. (c) 2007 Elsevier B.V. All rights reserved.
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页码：93 / 101
页数：9
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