Clinical Implications of the Cancer Genome

被引：148

作者：

MacConaill, Laura E.

Garraway, Levi A. ^{[1
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Ctr Canc Genome Discovery, Boston, MA 02115 USA

来源：

JOURNAL OF CLINICAL ONCOLOGY | 2010年 / 28卷 / 35期

关键词：

SMALL-CELL LUNG; LINEAGE-SURVIVAL ONCOGENE; TRANS-RETINOIC ACID; C-MYC; SOMATIC MUTATIONS; IMATINIB MESYLATE; HUMAN BREAST; PHASE-II; LEUKEMIA; GENE;

D O I：

10.1200/JCO.2009.27.4944

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Cancer is a disease of the genome. Most tumors harbor a constellation of structural genomic alterations that may dictate their clinical behavior and treatment response. Whereas elucidating the nature and importance of these genomic alterations has been the goal of cancer biologists for several decades, ongoing global genome characterization efforts are revolutionizing both tumor biology and the optimal paradigm for cancer treatment at an unprecedented scope. The pace of advance has been empowered, in large part, through disruptive technological innovations that render complete cancer genome characterization feasible on a large scale. This article highlights cardinal biologic and clinical insights gleaned from systematic cancer genome characterization. We also discuss how the convergence of cancer genome biology, technology, and targeted therapeutics articulates a cohesive framework for the advent of personalized cancer medicine.

引用

页码：5219 / 5227

页数：9

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