A pyran-2-one and four meroterpenoids from Thapsia transtagana and their implication in the biosynthesis of transtaganolides

被引：26

作者：

Rubal, Juan J.

Moreno-Dorado, F. J.

Guerra, Francisco M.

Zacarias, D. Jorge

Abderrahmane, Saouf

Mohamed., Akssira

Fouad, Mellouki

Raul, Romero-Garrido

Massanet, Guillermo M. ^{[1
]}

机构：

[1] Univ Cadiz, Fac Ciencias, Dept Quim Organ, Cadiz 11510, Spain

[2] Univ Hassan II Mohammedia, LCBA, UFR, Fac Sci & Tech, Mohammadia 20650, Morocco

来源：

PHYTOCHEMISTRY | 2007年 / 68卷 / 19期

关键词：

thapsia transtagana; Apiaceae; meroterpenoids; transtaganolides; prenylated coumarin; guaianolide; secocoumarin; thapsianolide; biogenetic hypothesis;

D O I：

10.1016/j.phytochem.2007.06.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Four meroterpenoids (3a, 3b, 4 and 5), a prenylated pyran-2-one (2) along with the known compounds 7-O-geranylscopoletin (1), and thapsitranstagin (6) have been isolated from the roots of Thapsia transtagana. The presence of I and 2 supports the biogenetic hypothesis that transtaganolides, a group of bioactive metabolites, are meroterpenoids which come from an O-prenylated coumarin via successive pericyclic reactions. (C) 2007 Elsevier Ltd. All rights reserved.

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收藏

页码：2480 / 2486

页数：7

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