Smad3 mutant mice develop metastatic colorectal cancer

被引：550

作者：

Zhu, YA

Richardson, JA

Parada, LF

Graff, JM

机构：

[1] Univ Texas, SW Med Ctr, Ctr Dev Biol, Dallas, TX 75235 USA

[2] Univ Texas, SW Med Ctr, Dept Pathol, Dallas, TX 75235 USA

来源：

CELL | 1998年 / 94卷 / 06期

关键词：

D O I：

10.1016/S0092-8674(00)81730-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

TGF beta-related growth factors have been implicated in a variety of developmental and physiological processes in organisms ranging from nematodes to mammals. TGF beta transduces its signal to the interior of the cell via Smad2, Smad3, and Smad4. We report the cloning and targeted disruption of the mouse Smad3 gene. Smad3 mutant mice are viable and fertile. Between 4 and 6 months of age, the Smad3 mutant mice become moribund with colorectal adenocarcinomas. The neoplasms penetrate through the intestinal wall and metastasize to lymph nodes. These results directly implicate TGF beta signaling in the pathogenesis of colorectal cancer and provide a compelling animal model for the study of human colorectal cancer.

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收藏

页码：703 / 714

页数：12

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