Early life events and conditions and breast cancer risk: From epidemiology to etiology

被引：91

作者：

Trichopoulos, Dimitrios ^{[1
]}

Adami, Hans-Olov ^{[1
,2
]}

Ekbom, Anders ^{[3
]}

Hsieh, Chung-Cheng ^{[1
,4
]}

Lagiou, Pagona ^{[1
,5
]}

机构：

[1] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA

[2] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[3] Karolinska Univ Hosp, Karolinska Inst, Dept Med, Clin Epidemiol Unit, Stockholm, Sweden

[4] Univ Massachusetts, Sch Med, Dept Canc Biol & Canc Ctr, Worcester, MA USA

[5] Univ Athens, Sch Med, Dept Hyg & Epidemiol, GR-10679 Athens, Greece

来源：

INTERNATIONAL JOURNAL OF CANCER | 2008年 / 122卷 / 03期

关键词：

breast cancer; perinatal; birth weight; stem cells; hormones; pregnancy;

D O I：

10.1002/ijc.23303

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Risk factors for breast cancer-documented by intensive epidemiological investigations and viewed in the context of general principles of carcinogenesis-can be integrated to an etiologic model comprising 3 principal components: the likelihood of breast cancer occurrence depends on the number of mammary tissue-specific stem cells, which is determined in early life; all growth-enhancing mammotropic hormones affect the rate of expansion of initiated clones; and while a pregnancy stimulates the replication of already initiated cells, it conveys long-term protection through differentiation of mammary tissue-specific stem cells. This perspective accommodates much of what is known about the epidemiology and natural history of breast cancer and highlights the role of early life in the origin of this cancer. (c) 2007 Wiley-Liss, Inc.

引用

页码：481 / 485

页数：5

共 84 条

[11] A traditional Mediterranean diet decreases endogenous estrogens in healthy postmenopausal women [J].

Carruba, Giuseppe ;

Granata, Orazia M. ;

Pala, Valeria ;

Campisi, Ildegarda ;

Agostara, Biagio ;

Cusimano, Rosanna ;

Ravazzolo, Barbara ;

Traina, Adele .

NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2006, 56 (02) :253-259

[12] Prenatal and perinatal correlates of adult mammographic breast density [J].

Cerhan, JR ;

Sellers, TA ;

Janney, CA ;

Pankratz, VS ;

Brandt, KR ;

Vachon, CM .

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2005, 14 (06) :1502-1508

[13] Influence of estrogen plus progestin on breast, cancer and mammography in healthy postmenopausal women - The Women's Health Initiative Randomized trial [J].

Chlebowski, RT ;

Hendrix, SL ;

Langer, RD ;

Stefanick, ML ;

Gass, M ;

Lane, D ;

Rodabough, RJ ;

Gilligan, MA ;

Cyr, MG ;

Thomson, CA ;

Khandekar, J ;

Petrovitch, H ;

McTiernan, A .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 289 (24) :3243-3253

[14]

Claus EB, 1996, CANCER, V77, P2318, DOI 10.1002/(SICI)1097-0142(19960601)77:11<2318::AID-CNCR21>3.0.CO

[15]

2-Z

[16] FAMILY HISTORY, AGE, AND RISK OF BREAST-CANCER - PROSPECTIVE DATA FROM THE NURSES HEALTH STUDY [J].

COLDITZ, GA ;

WILLETT, WC ;

HUNTER, DJ ;

STAMPFER, MJ ;

MANSON, JE ;

HENNEKENS, CH ;

ROSNER, BA ;

SPEIZER, FE .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1993, 270 (03) :338-343

[17]

COLE P, 1969, LANCET, V1, P604

[18] Timing of dietary estrogenic exposures and breast cancer risk [J].

De Assis, Sonia ;

Hilakivi-Clarke, Leena .

ESTROGENS AND HUMAN DISEASES, 2006, 1089 :14-35

[19] A UNIFYING CONCEPT OF THE ETIOLOGY OF BREAST-CANCER [J].

DEWAARD, F ;

TRICHOPOULOS, D .

INTERNATIONAL JOURNAL OF CANCER, 1988, 41 (05) :666-669

[20]

Dorgan JF, 2002, JNCI-J NATL CANCER I, V94, P606

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