Diastereomeric phosphite-pyridine ligands for enantioselective 1,4-conjugate additions

被引：17

作者：

Luo, XC ^{[1
]}

Hu, YC ^{[1
]}

Hu, XQ ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

来源：

TETRAHEDRON-ASYMMETRY | 2005年 / 16卷 / 06期

关键词：

D O I：

10.1016/j.tetasy.2005.02.002

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Diastercomeric phosphite-pyridine ligands derived from racemic biphenyl units and homochiral BINOL, achieved high enantioselectivities (up to 96.1%, ee) in the Cu(l)-catalysed conjugate additions Of Et2Zn to a variety of acyclic enones. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1227 / 1231

页数：5

共 57 条

[1] Atropos but achiral tris(phosphanyl)biphenyl ligands for RU-catalyzed asymmetric hydrogenation [J].

Aikawa, K ;

Mikami, K .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (44) :5455-5458

[2] Biphenol-based ligands for Cu-catalyzed asymmetric conjugate addition [J].

Alexakis, A ;

Polet, D ;

Benhaim, C ;

Rosset, S .

TETRAHEDRON-ASYMMETRY, 2004, 15 (14) :2199-2203

[3] Dramatic improvement of the enantiomeric excess in the asymmetric conjugate addition reaction using new experimental conditions [J].

Alexakis, A ;

Benhaim, C ;

Rosse, S ;

Humam, M .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (19) :5262-5263

[4]

Alexakis A, 2001, SYNLETT, P1375

[5] Asymmetric conjugate addition of diethyl zinc to enones with chiral phosphorus ligands derived from TADDOL [J].

Alexakis, A ;

Vastra, J ;

Burton, J ;

Benhaim, C ;

Mangeney, P .

TETRAHEDRON LETTERS, 1998, 39 (43) :7869-7872

[6]

Alexakis A, 2002, EUR J ORG CHEM, V2002, P3221

[7]

Bolm C, 2000, CHIRALITY, V12, P523, DOI 10.1002/(SICI)1520-636X(2000)12:5/6<523::AID-CHIR39>3.3.CO

[8]

2-Q

[9] Efficient cu-catalyzed asymmetric conjugate additions of alkylzincs to trisubstituted cyclic enones [J].

Degrado, SJ ;

Mizutani, H ;

Hoveyda, AH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2002, 124 (45) :13362-13363

[10] Modular peptide-based phosphine ligands-in asymmetric catalysis: Efficient and enantioselective Cu-catalyzed conjugate additions to five-, six-, and seven-membered cyclic enones [J].

Degrado, SJ ;

Mizutani, H ;

Hoveyda, AH .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (04) :755-756

← 1 2 3 4 5 6 →