QSAR of apoptosis induction in various cancer cells

被引：14

作者：

Hansch, C ^{[1
]}

Jazirehi, A

Mekapati, SB

Garg, R

Bonavida, B

机构：

[1] Pomona Coll, Dept Chem, Claremont, CA 91711 USA

[2] Univ Calif Los Angeles, Dept Microbiol Mol Genet & Immunol, Los Angeles, CA 90095 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2003年 / 11卷 / 13期

关键词：

D O I：

10.1016/S0968-0896(03)00184-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In continuing our QSAR study of apoptosis, we consider in this report the action of phenolic compounds on Ramos cells (non-Hodgkins B-cell lymphoma): the effect of O-8-thapsigargin analogues on human prostate cancer cells, Tsu-Pr-1 and the induction of apoptosis of a complex set of congeners on human fibrosarcoma cells HT 1080. The human prostate cancer cells activity is very similar to that of the Ramos cells. While the QSAR for the fibrosarcoma cells resembles that of our earlier study with L1210 leukemia cells. The two different types of QSAR suggest at least two quite different types of receptors for the induction of apoptosis. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：3015 / 3019

页数：5

共 14 条

[1]

[Anonymous], CELLS DIE

[2] Death receptors: Signaling and modulation [J].