Basic concepts in the study of diseases with complex genetics

被引：53

作者：

Burmeister, M ^{[1
]}

机构：

[1] Univ Michigan, Mental Hlth Res Inst, Ann Arbor, MI 48109 USA

来源：

BIOLOGICAL PSYCHIATRY | 1999年 / 45卷 / 05期

关键词：

complex genetics; psychiatric genetics; association; linkage;

D O I：

10.1016/S0006-3223(98)00316-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Most diseases run in families-this is also true of virtually all psychiatric disorders. Twin and adoption studies have shown that most psychiatric disorders have a genetic component, yet very few genetic factors are known, as is true for most disorders with a complex genetic origin. Here I review for nongeneticists, some of the basic terminology and concepts used when studying complex genetic diseases, with examples from psychiatric genetics. This review is intended to help in the understanding and critical evaluation of reports on genetics of psychiatric illnesses in the literature. Biol Psychiatry 1999;45: 522-532 (C) 1999 Society of Biological Psychiatry.

引用

页码：522 / 532

页数：11

共 48 条

[21] GENETIC DISSECTION OF COMPLEX TRAITS - GUIDELINES FOR INTERPRETING AND REPORTING LINKAGE RESULTS [J].

LANDER, E ;

KRUGLYAK, L .

NATURE GENETICS, 1995, 11 (03) :241-247

[22] GENETIC DISSECTION OF COMPLEX TRAITS [J].

LANDER, ES ;

SCHORK, NJ .

SCIENCE, 1994, 265 (5181) :2037-2048

[23] Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region [J].

Lesch, KP ;

Bengel, D ;

Heils, A ;

Sabol, SZ ;

Greenberg, BD ;

Petri, S ;

Benjamin, J ;

Muller, CR ;

Hamer, DH ;

Murphy, DL .

SCIENCE, 1996, 274 (5292) :1527-1531

[24] Benefits and pitfalls encountered in psychiatric genetic association studies [J].

Malhotra, AK ;

Goldman, D .

BIOLOGICAL PSYCHIATRY, 1999, 45 (05) :544-550

[25] THE GENETICS OF BIPOLAR DISORDER [J].

MITCHELL, P ;

MACKINNON, A ;

WATERS, B .

AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, 1993, 27 (04) :560-580

[26] A COMPREHENSIVE HUMAN LINKAGE WITH CENTIMORGAN DENSITY [J].

MURRAY, JC ;

BUETOW, KH ;

WEBER, JL ;

LUDWIGSEN, S ;

SCHERPBIERHEDDEMA, T ;

MANION, F ;

QUILLEN, J ;

SHEFFIELD, VC ;

SUNDEN, S ;

DUYK, GM ;

WEISSENBACH, J ;

GYAPAY, G ;

DIB, C ;

MORRISSETTE, J ;

LATHROP, GM ;

VIGNAL, A ;

WHITE, R ;

MATSUNAMI, N ;

GERKEN, S ;

MELIS, R ;

ALBERTSEN, H ;

PLAETKE, R ;

ODELBERG, S ;

WARD, D ;

DAUSSET, J ;

COHEN, D ;

CANN, H .

SCIENCE, 1994, 265 (5181) :2049-2054

[27]

*NAT I MENT HLTH, 1998, GEN MENT DIS

[28] DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene [J].

Nickerson, DA ;

Taylor, SL ;

Weiss, KM ;

Clark, AG ;

Hutchinson, RG ;

Stengård, J ;

Salomaa, V ;

Vartiainen, E ;

Boerwinkle, E ;

Sing, CF .

NATURE GENETICS, 1998, 19 (03) :233-240

[29] COMPLEX SEGREGATION ANALYSES OF OLD ORDER AMISH FAMILIES ASCERTAINED THROUGH BIPOLAR-I INDIVIDUALS [J].

PAULS, DL ;

BAILEY, JN ;

CARTER, AS ;

ALLEN, CR ;

EGELAND, JA .

AMERICAN JOURNAL OF MEDICAL GENETICS, 1995, 60 (04) :290-297

[30]

Peltonen L, 1995, BIOL CHEM H-S, V376, P697

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