Altered gene expression in the superior temporal gyrus in schizophrenia

被引:62
作者
Bowden, Nikola A. [1 ,2 ,3 ]
Scott, Rodney J. [1 ,2 ,3 ,4 ]
Tooney, Paul A. [1 ,2 ,3 ]
机构
[1] Neurosci Inst Schizophrenia & Allied Disorders, Sydney, NSW, Australia
[2] John Hunter Hosp, Hunter Med Res Inst, Brain & Mental Hlth Res Program, New Lambton Heights, NSW, Australia
[3] Univ Newcastle, Sch Biomed Sci, Callaghan, NSW 2308, Australia
[4] John Hunter Hosp, Div Genet, Hunter Area Pathol Serv, New Lambton Heights 2305, Australia
关键词
D O I
10.1186/1471-2164-9-199
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Background: The superior temporal gyrus (STG), which encompasses the primary auditory cortex, is believed to be a major anatomical substrate for speech, language and communication. The STG connects to the limbic system (hippocampus and amygdala), the thalamus and neocortical association areas in the prefrontal cortex, all of which have been implicated in schizophrenia. Results: To identify altered mRNA expression in the superior temporal gyrus (STG) in schizophrenia, oligonucleotide microarrays were used with RNA from postmortem STG tissue from 7 individuals with schizophrenia and 7 matched non-psychiatric controls. Overall, there was a trend towards down-regulation in gene expression, and altered expression of genes involved in neurotransmission, neurodevelopment, and presynaptic function was identified. To confirm altered expression identified by microarray analysis, the mRNA expression levels of four genes, IPLA2 gamma, PIK31R1, Lin-7b and ATBF1, were semi-quantitatively measured using relative real-time PCR. A number of genes with altered expression in the STG were also shown to have similar changes in expression as shown in our previous study of peripheral blood lymphocytes in schizophrenia. Conclusion: This study has identified altered expression of genes in the STG involved in neurotransmission and neurodevelopment, and to a lesser extent presynaptic function, which further support the notion of these functions playing an integral role in the development of schizophrenia.
引用
收藏
页数:12
相关论文
共 55 条
[21]   Altered expression of mitochondria-related genes in postmortem brains of patients with bipolar disorder or schizophrenia, as revealed by large-scale DNA microarray analysis [J].
Iwamoto, K ;
Bundo, M ;
Kato, T .
HUMAN MOLECULAR GENETICS, 2005, 14 (02) :241-253
[22]   Differential modulation of NR1-NR2A and NR1-NR2B subtypes of NMDA receptor by PDZ domain-containing proteins [J].
Iwamoto, T ;
Yamada, Y ;
Hori, K ;
Watanabe, Y ;
Sobue, K ;
Inui, M .
JOURNAL OF NEUROCHEMISTRY, 2004, 89 (01) :100-108
[23]   Characterization of MALS/velis-1, -2, and -3: a family of mammalian LIN-7 homologs enriched at brain synapses in association with the postsynaptic density-95 NMDA receptor postsynaptic complex [J].
Jo, K ;
Derin, R ;
Li, M ;
Bredt, DS .
JOURNAL OF NEUROSCIENCE, 1999, 19 (11) :4189-4199
[24]   Homeotic factor ATBF1 induces the cell cycle arrest associated with neuronal differentiation [J].
Jung, CG ;
Kim, HJ ;
Kawaguchi, M ;
Khanna, KK ;
Hida, H ;
Asai, K ;
Nishino, H ;
Miura, Y .
DEVELOPMENT, 2005, 132 (23) :5137-5145
[25]  
KATSEL P, 2005, SCHIZOPHRENIA RES
[26]   Identification and distribution of endoplasmic reticulum iPLA2 [J].
Kinsey, GR ;
Cummings, BS ;
Beckett, CS ;
Saavedra, G ;
Zhang, WL ;
McHowat, J ;
Schnellmann, RG .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2005, 327 (01) :287-293
[27]   Fluorometric assays of phospholipase A2 activity with three different substrates in biological samples of patients with schizophrenia [J].
Lasch, J ;
Willhardt, I ;
Kinder, D ;
Sauer, H ;
Smesny, S .
CLINICAL CHEMISTRY AND LABORATORY MEDICINE, 2003, 41 (07) :908-914
[28]   Increased levels of expression of an NMDARI splice variant in the superior temporal gyrus in schizophrenia [J].
Le Corre, S ;
Harper, CG ;
Lopez, P ;
Ward, P ;
Catts, S .
NEUROREPORT, 2000, 11 (05) :983-986
[29]   Towards understanding the schizophrenia code: An expanded convergent functional genomics approach [J].
Le-Niculescu, H. ;
Balaraman, Y. ;
Patel, S. ;
Tan, J. ;
Sidhu, K. ;
Jerome, R. E. ;
Edenberg, H. J. ;
Kuczenski, R. ;
Geyer, M. A. ;
Nurnberger, J. I., Jr. ;
Faraone, S. V. ;
Tsuang, M. T. ;
Niculescu, A. B. .
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2007, 144B (02) :129-158
[30]   Superior temporal gyral volumes and laterality correlates of auditory hallucinations in schizophrenia [J].
Levitan, C ;
Ward, PB ;
Catts, SV .
BIOLOGICAL PSYCHIATRY, 1999, 46 (07) :955-962