Novel neurotransmitters as natural ligands of orphan G-protein-coupled receptors

被引：113

作者：

Civelli, O

Nothacker, HP

Saito, Y

Wang, ZW

Lin, SHS

Reinscheid, RK

机构：

[1] Univ Calif Irvine, Dept Pharmacol, Irvine, CA 92697 USA

[2] Univ Calif Irvine, Dept Dev & Cell Biol, Irvine, CA 92697 USA

[3] NeoGene Technol, Irvine, CA 92612 USA

来源：

TRENDS IN NEUROSCIENCES | 2001年 / 24卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0166-2236(00)01763-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The 'orphan' G-protein-coupled receptors (GPCRs) are cloned GPCRs that bind unknown ligands. Since 1995, nineteen orphan GPCRs have been used as targets to identify and isolate their natural ligands via the application of the 'orphan receptor strategy'. These ligands are peptides, lipids or biogenic amines, and act as transmitter molecules. One nucleotide-sugar derivative and six peptides or peptide families identified through this strategy are novel and have already enriched our understanding of various brain functions.

引用

页码：230 / 237

页数：8

共 74 条

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