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Genetic mapping and chromosome localization of the rat mitochondrial glycerol-3-phosphate dehydrogenase gene, a candidate for non-insulin-dependent diabetes mellitus

被引：16
作者：
Koike, G
VanVooren, P
Shiozawa, M
Galli, J
Li, LS
Glaser, A
Balasubramanyam, A
Brown, LJ
Luthman, H
Szpirer, C
MacDonald, MJ
Jacob, HJ
机构：
[1] MASSACHUSETTS GEN HOSP EAST,CARDIOVASC RES CTR,CHARLESTOWN,MA 02129
[2] FREE UNIV BRUSSELS,DEPT BIOL MOL,B-1640 RHODE ST GENESE,BELGIUM
[3] KAROLINSKA HOSP,DEPT MOL MED,ROLF LUFT CTR DIABET RES,S-17176 STOCKHOLM,SWEDEN
[4] UNIV WISCONSIN,SCH MED,CHILDREN DIABET CTR,MADISON,WI 53706
来源：
GENOMICS | 1996年 / 38卷 / 01期
关键词：
D O I：
10.1006/geno.1996.0599
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The mitochondrial FAD-dependent glycerol-3-phosphate dehydrogenase (mtGPD) plays an important role in the regulation of insulin secretion and has been postulated as a candidate responsible for the pathogenesis of non-insulin-dependent diabetes mellitus (NIDDM) in humans as well as in rodent models of NIDDM. Recent molecular genetic studies of the Goto-Kakizaki (GK) rat model of NIDDM have identified loci linked to NIDDM. To elucidate whether rat mtGPD might play a role in the pathogenesis of NIDDM, the rat mtGPD gene (Gpd2) was cloned, and a genetic marker for Gpd2 was developed. The gene mapped to the region of rat chromosome 3 that contains a region linked to NIDDM in the GK rat. Fluorescence in situ hybridization was also carried out to verify the map position. (C) 1996 Academic Press, Inc.
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收藏
页码：96 / 99
页数：4
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