Novel types of L-proline-based binaphthyl sulfonimides and sulfonamides were found to be efficient organocatalysts for the asymmetric Michael addition of ketones to nitroalkenes to provide optically active gamma-nitroketone derivatives of synthetic and biological importance. After the fine optimization of solvents, temperature, and additive, good to excellent enantioselectivities and diastereoselectivities (71-96 % ee, up to >99:1 dr) can be achieved.
机构:
Univ Penn, Dept Chem, P Roy & Diane T Vagelos Labs, Philadelphia, PA 19104 USAUniv Penn, Dept Chem, P Roy & Diane T Vagelos Labs, Philadelphia, PA 19104 USA
Balsells, J
Walsh, PJ
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Univ Penn, Dept Chem, P Roy & Diane T Vagelos Labs, Philadelphia, PA 19104 USAUniv Penn, Dept Chem, P Roy & Diane T Vagelos Labs, Philadelphia, PA 19104 USA
机构:
Stockholm Univ, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, SwedenStockholm Univ, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden
Dahlin, N
Bogevig, A
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Stockholm Univ, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, SwedenStockholm Univ, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden
机构:
Univ Penn, Dept Chem, P Roy & Diane T Vagelos Labs, Philadelphia, PA 19104 USAUniv Penn, Dept Chem, P Roy & Diane T Vagelos Labs, Philadelphia, PA 19104 USA
Balsells, J
Walsh, PJ
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机构:
Univ Penn, Dept Chem, P Roy & Diane T Vagelos Labs, Philadelphia, PA 19104 USAUniv Penn, Dept Chem, P Roy & Diane T Vagelos Labs, Philadelphia, PA 19104 USA
机构:
Stockholm Univ, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, SwedenStockholm Univ, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden
Dahlin, N
Bogevig, A
论文数: 0引用数: 0
h-index: 0
机构:
Stockholm Univ, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, SwedenStockholm Univ, Arrhenius Lab, Dept Organ Chem, SE-10691 Stockholm, Sweden