Role of regulatory invariant CD1d-Restricted natural killer T-cells in protection against type 1 diabetes

被引：10

作者：

Hussain, S

Wagner, M

Ly, D

Delovitch, TL

机构：

[1] Robarts Res Inst, Autoimmun Diabet Grp, London, ON N6G 2V4, Canada

[2] Univ Western Ontario, Dept Microbiol & Immunol, London, ON, Canada

来源：

IMMUNOLOGIC RESEARCH | 2005年 / 31卷 / 03期

基金：

加拿大健康研究院;

关键词：

invariant CD1d-restricted natural killer T cells; type; 1; diabetes; nonobese diabetic mice; regulatory T cells; immunoregulation;

D O I：

10.1385/IR:31:3:177

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Invariant CD1d-restricted natural killer T (iNKT) cells function during innate and adaptive immune responses. A functional and numerical deficiency of iNKT cells is well documented ill both nonobese diabetic (NOD) mice and humans with autoimmune type 1 diabetes (T1D). Restoring the numerical and/or functional deficiency of iNKT cells in NOD mice by either treatment with alpha-galactosylceramide, transgenic induction of V alpha 14-J alpha 18 expression, or transgenic expression of CD1d in NOD islets under the control of the human insulin promoter confers protection from T1D in these mice. Recently, considerable progress has been made ill understanding the developmental and functional activities of iNKT cells. In this review, we discuss the role of iNKT cell deficiency and defective development in the onset of T1D in NOD mice and the different protective mechanisms known to restore these defects.

引用

收藏

页码：177 / 188

页数：12

相关论文

共 87 条

[1] Neonatal adaptive immunity comes of age [J].

Adkins, B ;

Leclerc, C ;

Marshall-Clarke, S .

NATURE REVIEWS IMMUNOLOGY, 2004, 4 (07) :553-564

[2] Th2 bias of CD4+ NKT cells derived from multiple sclerosis in remission [J].

Araki, M ;

Kondo, T ;

Gumperz, JE ;

Brenner, MB ;

Miyake, S ;

Yamamura, T .

INTERNATIONAL IMMUNOLOGY, 2003, 15 (02) :279-288

[3] Neonatal activation of CD28 signaling overcomes T cell anergy and prevents autoimmune diabetes by an IL-4-dependent mechanism [J].

Arreaza, GA ;

Cameron, MJ ;

Jaramillo, A ;

Gill, BM ;

Hardy, D ;

Laupland, KB ;

Rapoport, MJ ;

Zucker, P ;

Chakrabarti, S ;

Chensue, SW ;

Qin, HY ;

Singh, B ;

Delovitch, TL .

JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (09) :2243-2253

[4] The NOD mouse model of type 1 diabetes: As good as it gets? [J].

Atkinson, MA ;

Leiter, EH .

NATURE MEDICINE, 1999, 5 (06) :601-604

[5] Association between alpha beta TCR(+)CD4(-)CD8(-) T-cell deficiency and IDDM in NOD/Lt mice [J].

Baxter, AG ;

Kinder, SJ ;

Hammond, KJL ;

Scollay, R ;

Godfrey, DI .

DIABETES, 1997, 46 (04) :572-582

[6] NKT cells inhibit the onset of diabetes by impairing the development of pathogenic T cells specific for pancreatic β cells [J].

Beaudoin, L ;

Laloux, V ;

Novak, J ;

Lucas, B ;

Lehuen, A .

IMMUNITY, 2002, 17 (06) :725-736

[7] A thymic precursor to the NK T cell lineage [J].

Benlagha, K ;

Kyin, T ;

Beavis, A ;

Teyton, L ;

Bendelac, A .

SCIENCE, 2002, 296 (5567) :553-555

[8] Systemic NKT cell deficiency in NOD mice is not detected in peripheral blood: implications for human studies [J].

Berzins, SP ;

Kyparissoudis, K ;

Pellicci, DG ;

Hammond, KJ ;

Sidobre, S ;

Baxter, A ;

Smyth, MJ ;

Kronenberg, M ;

Godfrey, DI .

IMMUNOLOGY AND CELL BIOLOGY, 2004, 82 (03) :247-252

[9] A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1) [J].

Bleul, CC ;

Fuhlbrigge, RC ;

Casasnovas, JM ;

Aiuti, A ;

Springer, TA .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (03) :1101-1109

[10] Mechanism of CD1d-restricted natural killer T cell activation during microbial infection [J].

Brigl, M ;

Bry, L ;

Kent, SC ;

Gumperz, JE ;

Brenner, MB .

NATURE IMMUNOLOGY, 2003, 4 (12) :1230-1237

← 1 2 3 4 5 6 7 8 9 →