The reverse stop-signal model for CTLA4 function

被引：102

作者：

Rudd, Christopher E. ^{[1
,2
]}

机构：

[1] Univ Cambridge, Dept Pathol, Div Immunol, Cell Signalling Sect, Cambridge CB1 4QP, England

[2] Cambridge Inst Med Res, Cambridge CB2 OXY, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2008年 / 8卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nri2253

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Activation of the T-cell co-receptor cytotoxic T-lymphocyte antigen 4 (CTLA4) has a pivotal role in adjusting the threshold for T-cell activation and in preventing autoimmunity and massive tissue infiltration by T cells. Although many mechanistic models have been postulated, no single model has yet accounted for its overall function. In this Opinion article, I outline the strengths and weaknesses of the current models, and present a new 'reverse stop-signal model' to account for CTLA4 function.

引用

页码：153 / 160

页数：8

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