The reverse stop-signal model for CTLA4 function

被引：102

作者：

Rudd, Christopher E. ^{[1
,2
]}

机构：

[1] Univ Cambridge, Dept Pathol, Div Immunol, Cell Signalling Sect, Cambridge CB1 4QP, England

[2] Cambridge Inst Med Res, Cambridge CB2 OXY, England

来源：

NATURE REVIEWS IMMUNOLOGY | 2008年 / 8卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/nri2253

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Activation of the T-cell co-receptor cytotoxic T-lymphocyte antigen 4 (CTLA4) has a pivotal role in adjusting the threshold for T-cell activation and in preventing autoimmunity and massive tissue infiltration by T cells. Although many mechanistic models have been postulated, no single model has yet accounted for its overall function. In this Opinion article, I outline the strengths and weaknesses of the current models, and present a new 'reverse stop-signal model' to account for CTLA4 function.

引用

页码：153 / 160

页数：8

共 86 条

[31] Negative co-receptors on lymphocytes [J].

Greenwald, RJ ;

Latchman, YE ;

Sharpe, AH .

CURRENT OPINION IN IMMUNOLOGY, 2002, 14 (03) :391-396

[32] T-cell integrins: more than just sticking points [J].

Hogg, N ;

Laschinger, M ;

Giles, K ;

McDowall, A .

JOURNAL OF CELL SCIENCE, 2003, 116 (23) :4695-4705

[33] Distinct T cell dynamics in lymph nodes during the induction of tolerance and immunity [J].

Hugues, S ;

Fetler, L ;

Bonifaz, L ;

Helft, J ;

Amblard, F ;

Amigorena, S .

NATURE IMMUNOLOGY, 2004, 5 (12) :1235-1242

[34] Transgenic expression of CTLA-4 controls lymphoproliferation in IL-2-deficient mice [J].

Hwang, KW ;

Sweatt, WB ;

Mashayekhi, M ;

Palucki, DA ;

Sattart, H ;

Chuang, E ;

Alegre, ML .

JOURNAL OF IMMUNOLOGY, 2004, 173 (09) :5415-5424

[35] Regulatory T cells suppress systemic and mucosal immune activation to control intestinal inflammation [J].

Izcue, Ana ;

Coombes, Janine L. ;

Powrie, Fiona .

IMMUNOLOGICAL REVIEWS, 2006, 212 :256-271

[36] Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase [J].

Katagiri, K ;

Hattori, M ;

Minato, N ;

Irie, S ;

Takatsu, K ;

Kinashi, T .

MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (06) :1956-1969

[37] An essential role for Scurfin in CD4+CD25+ T regulatory cells [J].

Khattri, R ;

Cox, T ;

Yasayko, SA ;

Ramsdell, F .

NATURE IMMUNOLOGY, 2003, 4 (04) :337-342

[38] CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells [J].

Krummel, MF ;

Allison, JP .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 183 (06) :2533-2540

[39] Molecular basis of T cell inactivation by CTLA-4 [J].

Lee, KM ;

Chuang, E ;

Griffin, M ;

Khattri, R ;

Hong, DK ;

Zhang, WG ;

Straus, D ;

Samelson, LE ;

Thompson, CB ;

Bluestone, JA .

SCIENCE, 1998, 282 (5397) :2263-2266

[40] Cutting edge:: Cbl-b:: One of the key molecules tuning CD28- and CTLA-4-Mediated T cell costimulation [J].

Li, DD ;

Gál, I ;

Vermes, C ;

Alegre, ML ;

Chong, ASF ;

Chen, LP ;

Shao, Q ;

Adarichev, V ;

Xu, XM ;

Koreny, T ;

Mikecz, K ;

Finnegan, A ;

Glant, TT ;

Zhang, J .

JOURNAL OF IMMUNOLOGY, 2004, 173 (12) :7135-7139

← 1 2 3 4 5 6 7 8 9 →