Vitamin D in health and disease: Current perspectives

被引:228
作者
Zhang, Ran [2 ]
Naughton, Declan P. [1 ]
机构
[1] Kingston Univ, Sch Life Sci, Kingston upon Thames KT1 2EE, London, England
[2] AllergyMatters Ltd, Long Ditton Surrey KT6 5QG, England
关键词
BONE-MINERAL DENSITY; D DEFICIENCY; MULTIPLE-SCLEROSIS; CALCIUM SUPPLEMENTATION; 1,25-DIHYDROXYVITAMIN D-3; CANCER MORTALITY; BLOOD-PRESSURE; ULTRAVIOLET-B; ORAL-HEALTH; TOOTH LOSS;
D O I
10.1186/1475-2891-9-65
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Despite the numerous reports of the association of vitamin D with a spectrum of development, disease treatment and health maintenance, vitamin D deficiency is common. Originating in part from the diet but with a key source resulting from transformation by exposure to sunshine, a great deal of the population suffers from vitamin D deficiency especially during winter months. It is linked to the treatment and pathogenesis and/or progression of several disorders including cancer, hypertension, multiple sclerosis, rheumatoid arthritis, osteoporosis, muscle weakness and diabetes. This widespread deficiency of Vitamin D merits consideration of widespread policies including increasing awareness among the public and healthcare professionals.
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页数:13
相关论文
共 174 条
[91]   Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial [J].
Lappe, Joan M. ;
Travers-Gustafson, Dianne ;
Davies, K. Michael ;
Recker, Robert R. ;
Heaney, Robert P. .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 2007, 85 (06) :1586-1591
[92]   Vitamin D and calcium supplementation prevents osteoporotic fractures in elderly community dwelling residents: A pragmatic population-based 3-year intervention study [J].
Larsen, ER ;
Mosekilde, L ;
Foldspang, A .
JOURNAL OF BONE AND MINERAL RESEARCH, 2004, 19 (03) :370-378
[93]   Vitamin D Deficiency An Important, Common, and Easily Treatable Cardiovascular Risk Factor? [J].
Lee, John H. ;
O'Keefe, James H. ;
Bell, David ;
Hensrud, Donald D. ;
Holick, Michael F. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2008, 52 (24) :1949-1956
[94]   SUNLIGHT, VITAMIN-D, AND OVARIAN-CANCER MORTALITY-RATES IN US WOMEN [J].
LEFKOWITZ, ES ;
GARLAND, CF .
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 1994, 23 (06) :1133-1136
[95]   Clinical aspects of vitamin D in the management of rheumatoid arthritis [J].
Leventis, P. ;
Patel, S. .
RHEUMATOLOGY, 2008, 47 (11) :1617-1621
[96]  
Li YC, 2002, J CLIN INVEST, V110, P229, DOI [10.1172/JCI200215219, 10.1172/JCI0215219]
[97]   LOW CIRCULATING VITAMIN-D IN OBESITY [J].
LIEL, Y ;
ULMER, E ;
SHARY, J ;
HOLLIS, BW ;
BELL, NH .
CALCIFIED TISSUE INTERNATIONAL, 1988, 43 (04) :199-201
[98]   The prevalence of vitamin D inadequacy amongst women with osteoporosis: an international epidemiological investigation [J].
Lips, P. ;
Hosking, D. ;
Lippuner, K. ;
Norquist, J. M. ;
Wehren, L. ;
Maalouf, G. ;
Ragi-Eis, S. ;
Chandler, J. .
JOURNAL OF INTERNAL MEDICINE, 2006, 260 (03) :245-254
[99]   Vitamin D deficiency and secondary hyperparathyroidism in the elderly: Consequences for bone loss and fractures and therapeutic implications [J].
Lips, P .
ENDOCRINE REVIEWS, 2001, 22 (04) :477-501
[100]   Vitamin D supplementation and fracture incidence in elderly persons - A randomized, placebo-controlled clinical trial [J].
Lips, P ;
Graafmans, WC ;
Ooms, ME ;
Bezemer, PD ;
Bouter, LM .
ANNALS OF INTERNAL MEDICINE, 1996, 124 (04) :400-+