Arginine conjugates of metallo-supramolecular cylinders prescribe helicity and enhance DNA junction binding and cellular activity

被引：44

作者：

Cardo, Lucia ^{[1
]}

Sadovnikova, Victoria ^{[1
]}

Phongtongpasuk, Siriporn ^{[1
]}

Hodges, Nikolas J. ^{[2
]}

Hannon, Michael J. ^{[1
]}

机构：

[1] Univ Birmingham, Sch Chem, Birmingham B15 2TT, W Midlands, England

[2] Univ Birmingham, Sch Biosci, Birmingham B15 2TT, W Midlands, England

来源：

CHEMICAL COMMUNICATIONS | 2011年 / 47卷 / 23期

关键词：

METALLOSUPRAMOLECULAR CYLINDERS; TRIPLE HELICATE; RECOGNITION; RESOLUTION; PEPTIDES; DESIGN;

D O I：

10.1039/c1cc11356a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The conjugation of arginine residues at the ends of a metallo-supramolecular triple-helical cylinder enables absolute control over the helicity of the cylinder core, and boosts the DNA junction recognition by the complexes and their activity against a cancer cell line.

引用

页码：6575 / 6577

页数：3

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