Stoichiometric and catalytic deuterium and tritium labeling of "unactivated" organic substrates with cationic Ir(III) complexes

被引：100

作者：

Skaddan, MB

Yung, CM

Bergman, RG

机构：

[1] Pfizer Inc, Pfizer Global Res & Dev, Kalamazoo, MI 49007 USA

[2] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[3] Lawrence Berkeley Lab, Div Chem Sci, Berkeley, CA 94720 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 01期

关键词：

D O I：

10.1021/ol0359923

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ir(III) complex [Cp*(PMe3)IrMe(CH2Cl2)][BArf] (1) was used to introduce deuterium stoichiometrically into substituted naphthalene/benzene templates and several "druglike" entities. The exchange process is tolerant of a wide array of functional groups. Labeling of warfarin using subatmospheric pressures of T-2 led to specific activities and total activities rivaling current functional group directed tritium labeling methods. When paired with the appropriate deuterium donor, Cp*(PMe3)Ir(H-3)OTf (4) was found to deuterate a number of organic compounds catalytically.

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页码：11 / 13

页数：3

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