Drugs from hidden bugs: their discovery via untapped resources

被引：34

作者：

Lefevre, Fabrice ^{[1
]}

Robe, Patrick ^{[1
]}

Jarrin, Cyrille ^{[1
]}

Ginolhac, Aurelien ^{[1
]}

Zago, Caroline ^{[1
]}

Auriol, Daniel ^{[1
]}

Vogel, Timothy M. ^{[2
]}

Simonet, Pascal ^{[2
]}

Nalin, Renaud ^{[1
]}

机构：

[1] LibraGen, F-31400 Toulouse, France

[2] Ecole Cent Lyon, Lab Ampere, Environm Microbial Genom Grp, CNRS,UMR 5005, F-69134 Ecully, France

来源：

RESEARCH IN MICROBIOLOGY | 2008年 / 159卷 / 03期

关键词：

metagenomics; environmental DNA extraction; drug discovery; high throughput screening;

D O I：

10.1016/j.resmic.2007.12.011

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The drug discovery process is a starving machine requiring constant feeding with new chemical compounds. Synthetic or natural scaffolds: what are the best sources? While synthetic molecules are rapidly generated by combinatorial chemistry, they show lower chemical diversity than their natural counterparts. A significant fraction of known natural products is issued from microbial secondary metabolism; however, more than 95% of bacterial organisms remain unexploited as a source of active chemical compounds due to their cultivation difficulties. Recent technological advances in metagenomics have provided reliable access to chemicals of these hidden bugs, thus opening up new opportunities for feeding the machine. (C) 2008 Elsevier Masson SAS. All rights reserved.

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收藏

页码：153 / 161

页数：9

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