A comparison of conventional and fast spin-echo sequences for the measurement of lesion load in multiple sclerosis using a semi-automated contour technique

被引：26

作者：

Rovaris, M ^{[1
]}

GawneCain, ML ^{[1
]}

Wang, L ^{[1
]}

Miller, DH ^{[1
]}

机构：

[1] UCL NATL HOSP NEUROL & NEUROSURG, NMR RES INST, NEUROL INST, LONDON WC1N 3BG, ENGLAND

来源：

NEURORADIOLOGY | 1997年 / 39卷 / 03期

关键词：

magnetic resonance imaging; multiple sclerosis; pulse sequences; lesion load;

D O I：

10.1007/s002340050384

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Changes on serial assessments of brain MRI lesion load are used for monitoring therapeutic efficacy in patients with multiple sclerosis (MS). We assessed the accuracy and reliability of conventional spin-echo (CSE) and fast spin-echo (FSE) sequences for measurement of lesion volume using a semiautomated contour technique. Cranial CSE and FSE examinations of 18 patients with secondary progressive MS were studied. The mean lesion load was slightly higher with the CSE sequence (p = 0.002). Intraobserver variability was significantly higher for FSE than for CSE, according to both the coefficient of variation between two measurements (mean 2.48 % and 1.35 % respectively, p < 0.05) and back-transformed 95 % limits of agreement (1.005-1.060 for FSE; 0.988-1.019 for CSE). Although FSE sequences are quicker and the total lesion volume measurements are similar to those obtained with CSE, the poorer reproducibility raises doubts about the use of FSE to replace CSE in clinical trials.

引用

页码：161 / 165

页数：5

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