Anti-angiogenic activity of tocotrienol

被引：66

作者：

Inokuchi, H ^{[1
]}

Hirokane, H ^{[1
]}

Tsuzuki, T ^{[1
]}

Nakagawa, K ^{[1
]}

Igarashi, M ^{[1
]}

Miyazawa, T ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Life Sci & Agr, Food & Biodynam Chem Lab, Sendai, Miyagi 9818555, Japan

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2003年 / 67卷 / 07期

关键词：

angiogenesis inhibitor; cancer; tocopherol; tocotrienol; vitamin E;

D O I：

10.1271/bbb.67.1623

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

The anti-angiogenic property of vitamin E compounds, with particular emphasis on tocotrienol, has been investigated in vitro. Tocotrienol, but not tocopherol, inhibited both the proliferation and tube formation of bovine aortic endothelial cells, with delta-tocotrienol appearing the highest activity. Also, delta-tocotrienol reduced the vascular endothelial growth factor-stimulated tube formation by human umbilical vein endothelial cells. Our findings suggest that tocotrienol has potential use as a therapeutic dietary supplement for minimizing tumor angiogenesis.

引用

页码：1623 / 1627

页数：5

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