Tumor Genetic Testing for Patient Selection in Phase I Clinical Trials: The Case of PI3K Inhibitors

被引:36
作者
Juric, Dejan [1 ]
Baselga, Jose [1 ,2 ]
机构
[1] Massachusetts Gen Hosp, Ctr Canc, Boston, MA 02114 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
关键词
DUAL PI3K/MTOR INHIBITOR; BREAST-CANCER CELLS; HEDGEHOG PATHWAY; MUTATIONS; SENSITIVITY; NVP-BEZ235; BRAF;
D O I
10.1200/JCO.2011.39.6390
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
引用
收藏
页码:765 / 766
页数:2
相关论文
共 18 条
[1]   Phase II Randomized Study of Neoadjuvant Everolimus Plus Letrozole Compared With Placebo Plus Letrozole in Patients With Estrogen Receptor-Positive Breast Cancer [J].
Baselga, Jose ;
Semiglazov, Vladimir ;
van Dam, Peter ;
Manikhas, Alexey ;
Bellet, Meritxell ;
Mayordomo, Jose ;
Campone, Mario ;
Kubista, Ernst ;
Greil, Richard ;
Bianchi, Giulia ;
Steinseifer, Jutta ;
Molloy, Betty ;
Tokaji, Erika ;
Gardner, Humphrey ;
Phillips, Penny ;
Stumm, Michael ;
Lane, Heidi A. ;
Dixon, J. Michael ;
Jonat, Walter ;
Rugo, Hope S. .
JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (16) :2630-2637
[2]   Specific apoptosis induction by the dual PI3K/mTor inhibitor NVP-BEZ235 in HER2 amplified and PIK3CA mutant breast cancer cells [J].
Brachmann, Saskia M. ;
Hofmann, Irmgard ;
Schnell, Christian ;
Fritsch, Christine ;
Wee, Susan ;
Lane, Heidi ;
Wang, Shaowen ;
Garcia-Echeverria, Carlos ;
Maira, Sauveur-Michel .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (52) :22299-22304
[3]   The phosphoinositide 3-kinase pathway [J].
Cantley, LC .
SCIENCE, 2002, 296 (5573) :1655-1657
[4]  
Coutre SE, 2011, ASCO M ABSTR S15, V29, p451s
[5]   Mutations of the BRAF gene in human cancer [J].
Davies, H ;
Bignell, GR ;
Cox, C ;
Stephens, P ;
Edkins, S ;
Clegg, S ;
Teague, J ;
Woffendin, H ;
Garnett, MJ ;
Bottomley, W ;
Davis, N ;
Dicks, N ;
Ewing, R ;
Floyd, Y ;
Gray, K ;
Hall, S ;
Hawes, R ;
Hughes, J ;
Kosmidou, V ;
Menzies, A ;
Mould, C ;
Parker, A ;
Stevens, C ;
Watt, S ;
Hooper, S ;
Wilson, R ;
Jayatilake, H ;
Gusterson, BA ;
Cooper, C ;
Shipley, J ;
Hargrave, D ;
Pritchard-Jones, K ;
Maitland, N ;
Chenevix-Trench, G ;
Riggins, GJ ;
Bigner, DD ;
Palmieri, G ;
Cossu, A ;
Flanagan, A ;
Nicholson, A ;
Ho, JWC ;
Leung, SY ;
Yuen, ST ;
Weber, BL ;
Siegler, HF ;
Darrow, TL ;
Paterson, H ;
Marais, R ;
Marshall, CJ ;
Wooster, R .
NATURE, 2002, 417 (6892) :949-954
[6]   Rapid targeted mutational analysis of human tumours: a clinical platform to guide personalized cancer medicine [J].
Dias-Santagata, Dora ;
Akhavanfard, Sara ;
David, Serena S. ;
Vernovsky, Kathy ;
Kuhlmann, Georgiana ;
Boisvert, Susan L. ;
Stubbs, Hannah ;
McDermott, Ultan ;
Settleman, Jeffrey ;
Kwak, Eunice L. ;
Clark, Jeffrey W. ;
Isakoff, Steven J. ;
Sequist, Lecia V. ;
Engelman, Jeffrey A. ;
Lynch, Thomas J. ;
Haber, Daniel A. ;
Louis, David N. ;
Ellisen, Leif W. ;
Borger, Darrell R. ;
Lafrate, A. John .
EMBO MOLECULAR MEDICINE, 2010, 2 (05) :146-158
[7]   Inhibition of Mutated, Activated BRAF in Metastatic Melanoma [J].
Flaherty, Keith T. ;
Puzanov, Igor ;
Kim, Kevin B. ;
Ribas, Antoni ;
McArthur, Grant A. ;
Sosman, Jeffrey A. ;
O'Dwyer, Peter J. ;
Lee, Richard J. ;
Grippo, Joseph F. ;
Nolop, Keith ;
Chapman, Paul B. .
NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (09) :809-819
[8]   The Evolving War on Cancer [J].
Haber, Daniel A. ;
Gray, Nathanael S. ;
Baselga, Jose .
CELL, 2011, 145 (01) :19-24
[9]   PI3K/AKT/mTOR Inhibitors in Patients With Breast and Gynecologic Malignancies Harboring PIK3CA Mutations [J].
Janku, Filip ;
Wheler, Jennifer J. ;
Westin, Shannon N. ;
Moulder, Stacy L. ;
Naing, Aung ;
Tsimberidou, Apostolia M. ;
Fu, Siqing ;
Falchook, Gerald S. ;
Hong, David S. ;
Garrido-Laguna, Ignacio ;
Luthra, Rajyalakshmi ;
Lee, J. Jack ;
Lu, Karen H. ;
Kurzrock, Razelle .
JOURNAL OF CLINICAL ONCOLOGY, 2012, 30 (08) :777-782
[10]   Anaplastic Lymphoma Kinase Inhibition in Non-Small-Cell Lung Cancer [J].
Kwak, Eunice L. ;
Bang, Yung-Jue ;
Camidge, D. Ross ;
Shaw, Alice T. ;
Solomon, Benjamin ;
Maki, Robert G. ;
Ou, Sai-Hong I. ;
Dezube, Bruce J. ;
Jaenne, Pasi A. ;
Costa, Daniel B. ;
Varella-Garcia, Marileila ;
Kim, Woo-Ho ;
Lynch, Thomas J. ;
Fidias, Panos ;
Stubbs, Hannah ;
Engelman, Jeffrey A. ;
Sequist, Lecia V. ;
Tan, WeiWei ;
Gandhi, Leena ;
Mino-Kenudson, Mari ;
Wei, Greg C. ;
Shreeve, S. Martin ;
Ratain, Mark J. ;
Settleman, Jeffrey ;
Christensen, James G. ;
Haber, Daniel A. ;
Wilner, Keith ;
Salgia, Ravi ;
Shapiro, Geoffrey I. ;
Clark, Jeffrey W. ;
Iafrate, A. John .
NEW ENGLAND JOURNAL OF MEDICINE, 2010, 363 (18) :1693-1703