Acetylated analogues of the microtubule-stabilizing agent discodermolide: Preparation and biological activity

被引：30

作者：

Gunasekera, SP ^{[1
]}

Longley, RE ^{[1
]}

Isbrucker, RA ^{[1
]}

机构：

[1] Harbor Branch Oceanog Inst Inc, Div Biomed Marine Res, Ft Pierce, FL 34946 USA

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 02期

关键词：

D O I：

10.1021/np000423e

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A series of eight discodermolide acetates have been prepared using natural (+)-discodermolide and evaluated for in vitro cytotoxicity against the cultured murine P-388 leukemia cells. The acetylated analogues showed a significant variation of cytotoxicity and suggested the importance of C-11 and C-17 hydroxyl groups for potency. The preparation and structure elucidation of the new analogues are described.

引用

页码：171 / 174

页数：4

共 32 条

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