Acetylated analogues of the microtubule-stabilizing agent discodermolide: Preparation and biological activity

被引:30
作者
Gunasekera, SP [1 ]
Longley, RE [1 ]
Isbrucker, RA [1 ]
机构
[1] Harbor Branch Oceanog Inst Inc, Div Biomed Marine Res, Ft Pierce, FL 34946 USA
来源
JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 02期
关键词
D O I
10.1021/np000423e
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
A series of eight discodermolide acetates have been prepared using natural (+)-discodermolide and evaluated for in vitro cytotoxicity against the cultured murine P-388 leukemia cells. The acetylated analogues showed a significant variation of cytotoxicity and suggested the importance of C-11 and C-17 hydroxyl groups for potency. The preparation and structure elucidation of the new analogues are described.
引用
收藏
页码:171 / 174
页数:4
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