Lack of replicative senescence in normal rodent glia

被引：149

作者：

Mathon, NF ^{[1
]}

Malcolm, DS ^{[1
]}

Harrisingh, MC ^{[1
]}

Cheng, LL ^{[1
]}

Lloyd, AC ^{[1
]}

机构：

[1] UCL, MRC, Mol Cell Biol Lab, London WC1E 6BT, England

来源：

SCIENCE | 2001年 / 291卷 / 5505期

关键词：

D O I：

10.1126/science.1056782

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Replicative senescence is thought to be an intrinsic mechanism for Limiting the proliferative Life-span of normal somatic cells. We show here that rat Schwann cells can be expanded indefinitely in culture while maintaining checkpoints normally Lost during the immortalization process. These findings demonstrate that senescence is not an inevitable consequence of extended proliferation in culture.

引用

页码：872 / 875

页数：4

共 14 条

[11] Inhibitors of cyclin-dependent kinases induce features of replicative senescence in early passage human diploid fibroblasts [J].