The DRESS Syndrome: A Literature Review

被引：682

作者：

Cacoub, Patrice ^{[1
,2
]}

Musette, Philippe ^{[3
,4
]}

Descamps, Vincent ^{[6
,7
]}

Meyer, Olivier ^{[8
]}

Speirs, Chris ^{[9
]}

Finzi, Laetitia ^{[10
]}

Roujeau, Jean Claude ^{[5
]}

机构：

[1] Hop La Pitie Salpetriere, AP HP, Dept Internal Med, F-75651 Paris 13, France

[2] Univ Paris 06, Paris, France

[3] Rouen Univ Hosp, Dept Dermatol, Rouen, France

[4] INSERM, U905, Rouen, France

[5] Henri Mondor Hosp, AP HP, Dept Dermatol, Creteil, France

[6] Univ Paris Est Creteil Val de Marne, Paris, France

[7] Bichat Claude Bernard Hosp, AP HP, Dept Dermatol, Paris, France

[8] Bichat Claude Bernard Hosp, AP HP, Dept Rheumatol, Paris, France

[9] Epsom & St Helies Univ Hosp NHS Trust, Surrey, England

[10] ClinSearch, Dept Med Writing, Bagneux, France

来源：

AMERICAN JOURNAL OF MEDICINE | 2011年 / 124卷 / 07期

关键词：

Drug hypersensitivity; Drug rash; Eosinophilia; HHV-6; Systemic symptoms; INDUCED HYPERSENSITIVITY SYNDROME; SYSTEMIC SYMPTOMS DRESS; CARBAMAZEPINE-INDUCED DRESS; HERPESVIRUS; 6; INFECTION; INDUCED DRUG REACTION; ACUTE-RENAL-FAILURE; POSITIVE PATCH-TEST; ANTICONVULSANT HYPERSENSITIVITY; HUMAN-HERPESVIRUS-6; REACTIVATION; TRANSIENT HYPOGAMMAGLOBULINEMIA;

D O I：

10.1016/j.amjmed.2011.01.017

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) is a severe adverse drug-induced reaction. Diagnosing DRESS is challenging due to the diversity of cutaneous eruption and organs involved. We used the RegiSCAR scoring system that grades DRESS cases as "no," "possible," "probable," or "definite" to classify cases reported in the literature. We also analyzed the clinical course and treatments of the cases. A total of 44 drugs were associated with the 172 cases reported between January 1997 and May 2009 in PubMed and MEDLINE. The most frequently reported drug was carbamazepine, and the vast majority of cases were classified as "probable/definite" DRESS cases. Hypereosinophilia, liver involvement, fever, and lymphadenopathy were significantly associated with "probable/definite" DRESS cases, whereas skin rash was described in almost all of the cases, including "possible cases." Culprit drug withdrawal and corticosteroids constituted the mainstay of DRESS treatment. The outcome was death in 9 cases. However, no predictive factors for serious cases were found. This better knowledge of DRESS may contribute to improve the diagnosis and management of this syndrome in clinical practice. (C) 2011 Elsevier Inc. All rights reserved. The American Journal of Medicine (2011) 124, 588-597

引用

页码：588 / 597

页数：10

共 145 条

[1] Carbamazepine-induced hypersensitivity syndrome associated with transient hypogammaglobulinaemia and reactivation of human herpesvirus 6 infection demonstrated by real-time quantitative polymerase chain reaction [J].