Frequency of lower respiratory tract infections in relation to adaptive immunity in children with Down syndrome compared to their healthy siblings

被引：53

作者：

Broers, Chantal J. M. ^{[1
]}

Gemke, Reinoud J. B. J. ^{[1
]}

Weijerman, Michel E. ^{[1
]}

Kuik, Dirk-J ^{[2
]}

van Hoogstraten, Ingrid M. W. ^{[3
]}

van Furth, A. Marceline ^{[4
]}

机构：

[1] Vrije Univ Amsterdam Med Ctr, Dept Pediat, NL-1081 HV Amsterdam, Netherlands

[2] Vrije Univ Amsterdam Med Ctr, Dept Epidemiol & Biostat, NL-1081 HV Amsterdam, Netherlands

[3] Vrije Univ Amsterdam Med Ctr, Dept Pathol, NL-1081 HV Amsterdam, Netherlands

[4] Vrije Univ Amsterdam Med Ctr, Dept Pediat Infect Dis Immunol & Rheumatol, NL-1081 HV Amsterdam, Netherlands

来源：

ACTA PAEDIATRICA | 2012年 / 101卷 / 08期

关键词：

Down syndrome; Immunoglobulins; NKT cells; Regulatory T cells; Respiratory tract infections; T cells; INTRINSIC DEFECT; LYMPHOCYTE SUBPOPULATIONS; YOUNG-CHILDREN; T-CELLS; VIRUS; COUNTS; SYSTEM; RISK;

D O I：

10.1111/j.1651-2227.2012.02696.x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Aim: Children with Down syndrome (DS) experience respiratory tract infections (RTIs) more frequently than healthy children. We investigated whether this is related to different immunological characteristics associated with DS. Methods: The study group consisted of 22 children with DS and 22 of their healthy, age-range matched siblings. Data were collected on infections and hospitalizations because of lower RTIs. Immunoglobulin and IgG subclass levels in blood, as well as lymphocyte and T cell (subset) counts, were determined. Results: The children with DS had a significantly higher frequency of lower RTIs and related hospitalization than their siblings. We also found significantly reduced IgG2 levels as well as significantly lower counts of total lymphocytes, CD4+ T lymphocytes, CD4+ invariant natural killer (iNKT) cells and regulatory T cells in the DS group. Conclusion: In children with DS, reduced levels of IgG2, total lymphocytes, T lymphocytes, iNKT cells and regulatory T cells might contribute to their higher susceptibility to lower RTIs.

引用

页码：862 / 867

页数：6

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