Micrometric molecular histology of lipids by mass spectrometry imaging

被引：64

作者：

Touboul, David ^{[1
]}

Laprevote, Olivier ^{[1
,2
]}

Brunelle, Alain ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, Ctr Rech Gif, F-91198 Gif Sur Yvette, France

[2] Univ Paris 05, Fac Sci Pharmaceut & Biol, EA 4463, F-75006 Paris, France

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2011年 / 15卷 / 05期

关键词：

TOF-SIMS; MULTIVARIATE-ANALYSIS; MOUSE-BRAIN; MALDI-TOF; LOCALIZATION; TISSUE; CELL; EMISSION; SYSTEM; MUSCLE;

D O I：

10.1016/j.cbpa.2011.04.017

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Time-Of-Flight Secondary Ion Mass Spectrometry is compared to other mass spectrometry imaging techniques, and recent improvements of the experimental methods, driven by biological and biomedical applications, are described and discussed. This review shows that this method that can be considered as a micrometric molecular histology is particularly efficient for obtaining images of various lipid species at the surface of a tissue sample, without sample preparation, and with a routine spatial resolution of 1 mu m or less.

引用

页码：725 / 732

页数：8

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