Peptoid dendrimers-microwave-assisted solid-phase synthesis and transfection agent evaluation

被引：28

作者：

Diaz-Mochon, Juan J. ^{[1
]}

Fara, Mario A. ^{[1
]}

Sanchez-Martin, Rosario M. ^{[1
]}

Bradley, Mark ^{[1
]}

机构：

[1] Univ Edinburgh, Sch Chem, Edinburgh EH9 3JJ, Midlothian, Scotland

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 05期

关键词：

D O I：

10.1016/j.tetlet.2007.11.122

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three generations of peptoid-based dendrimers were synthesised by solid-phase methods, using N-Fmoc-N-(6-N'-Fmoc-aminohexyl)glycine as both the initiator core and the monomer unit, which offer an unusual dendrimeric periphery composed of both secondary and primary amines. The third generation compound proved to be an efficient mediator of transfection while displaying minimal cytotoxicity. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：923 / 926

页数：4

共 28 条

[21] Solid-phase dendrimer synthesis and the generation of super-high-loading resin beads for combinatorial chemistry [J].

Swali, V ;

Wells, NJ ;

Langley, GJ ;

Bradley, M .

JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (15) :4902-4903

[22] SYNTHETIC PEPTIDE VACCINE DESIGN - SYNTHESIS AND PROPERTIES OF A HIGH-DENSITY MULTIPLE ANTIGENIC PEPTIDE SYSTEM [J].

TAM, JP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (15) :5409-5413

[23] Dendrimers and combinatorial chemistry -: tools for fluorescent enhancement in protease assays [J].

Ternon, ML ;

Díaz-Mochón, JJ ;

Belsom, A ;

Bradley, M .

TETRAHEDRON, 2004, 60 (39) :8721-8728

[24] PAMAM dendrimer based macromolecules as improved contrast agents [J].

Venditto, Vincent J. ;

Regino, Celeste Aida S. ;

Brechbiel, Martin W. .

MOLECULAR PHARMACEUTICS, 2005, 2 (04) :302-311

[25]

VOJKOVSKY T, 1995, PEPTIDE RES, V8, P236

[26]

Wells NJ, 1998, BIOPOLYMERS, V47, P381, DOI 10.1002/(SICI)1097-0282(1998)47:5<381::AID-BIP5>3.0.CO

[27]

2-F

[28] PAMAM dendrimers for efficient siRNA delivery and potent gene silencing [J].

Zhou, Jiehua ;

Wu, Jiangyu ;

Hafdi, Nadia ;

Behr, Jean-Paul ;

Erbacher, Patrick ;

Peng, Ling .

CHEMICAL COMMUNICATIONS, 2006, (22) :2362-2364

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