Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription

被引：2024

作者：

Jones, PL

Veenstra, GJC

Wade, PA

Vermaak, D

Kass, SU

Landsberger, N

Strouboulis, J

Wolffe, AP ^{[1
]}

机构：

[1] NICHHD, Mol Embryol Lab, NIH, Bethesda, MD 20892 USA

[2] Janssen Res Fdn, Dept Expt Mol Biol, B-2340 Beerse, Belgium

[3] Univ Varese, Dipartimento Biol Strutturale & Funz, I-2100 Varese, Italy

来源：

NATURE GENETICS | 1998年 / 19卷 / 02期

关键词：

D O I：

10.1038/561

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

CpG methylation in vertebrates correlates with alterations in chromatin structure and gene silencing(1-4). Differences in DNA-methylation status are associated with imprinting phenomena and carcinogenesis(5-10). In Xenopus laevis oocytes, DNA methylation dominantly silences transcription through the assembly of a repressive nucleosomal array(11). Methylated DNA assembled into chromatin binds the transcriptional repressor MeCP2 which cofractionates with Sin3 and histone deacetylase. Silencing conferred by MeCP2 and methylated DNA can be relieved by inhibition of histone deacetylase, facilitating the remodeling of chromatin and transcriptional activation. These results establish a direct causal relationship between DNA methylation-dependent transcriptional silencing and the modification of chromatin.

引用

页码：187 / 191

页数：5

共 30 条

[21] Remodeling of regulatory nucleoprotein complexes on the Xenopus hsp70 promoter during meiotic maturation of the Xenopus oocyte [J].