MicroRNA in lung cancer

被引：181

作者：

Lin, P-Y ^{[1
,2
]}

Yu, S-L ^{[3
,4
]}

Yang, P-C ^{[1
,2
,4
]}

机构：

[1] Acad Sinica, Inst Biomed Sci, Taipei, Taiwan

[2] Natl Taiwan Univ Hosp, Dept Internal Med, Taipei 100, Taiwan

[3] Natl Taiwan Univ, Dept Clin & Lab Sci & Med Biotechnol, Taipei 10764, Taiwan

[4] Natl Taiwan Univ, Res Ctr Med Excellence, Div Genom Med, Taipei 10764, Taiwan

来源：

BRITISH JOURNAL OF CANCER | 2010年 / 103卷 / 08期

关键词：

lung cancer; microRNA; oncogene; tumour suppressor; risk stratification; personalised medicine; EXPRESSION PROFILES; GENE-EXPRESSION; POSTTRANSCRIPTIONAL REGULATION; REDUCED EXPRESSION; PREDICTS SURVIVAL; GROWTH; DROSHA; DICER; ADENOCARCINOMA; SIGNATURES;

D O I：

10.1038/sj.bjc.6605901

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs ( miRNAs) are small non-protein-coding RNAs that function as endogenous negative gene regulators. Dysfunctions of miRNAs are frequently found in malignancies, including lung cancer. In this review, we summarise the current understanding of miRNAs in lung cancer tumourigenesis, and highlight their potential in overcoming drug resistance, abetting histological sub-classification techniques, and serving as biomarkers for lung cancer risk stratification and outcome prediction. British Journal of Cancer ( 2010) 103, 1144-1148. doi:10.1038/sj.bjc.6605901 www.bjcancer.com Published online 21 September 2010 (C) 2010 Cancer Research UK

引用

页码：1144 / 1148

页数：5

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