Genetic studies of A2M and BACEI genes in Chinese Han Alzheimer's disease patients

被引：19

作者：

Cai, L

Tang, GM

Chen, LS

Zhang, BS

Jiang, SD

Ren, DM ^{[1
]}

机构：

[1] Fudan Univ, Sch Life Sci, Inst Genet, State Key Lab Genet Engn, Shanghai 200433, Peoples R China

[2] Shanghai Inst Mental Hlth, Shanghai, Peoples R China

来源：

NEUROREPORT | 2005年 / 16卷 / 09期

关键词：

Alzheimer's disease; alpha-2-macroglobulin; apolipoprotein E; beta-site amyloid precursor protein-cleaving enzyme;

D O I：

10.1097/00001756-200506210-00028

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated insertion (Ins)/deletion(Del) polymorphism in alpha-2-macroglobulin (A2M),G/C variant in the beta-site amyloid precursor protein-cleaving enzyme I (BACEI) and apolipoprotein E (APOE) gene epsilon 2/epsilon 3/epsilon 4 polymorphism in 387 Chinese Han ethnic patients with Alzheimer's disease and healthy study participants. After stratification for APO epsilon A status, only the BACEI-G allele with APOE epsilon 4 was significantly associated with Alzheimer's disease. Through meta-analysis of the Del or G allele by pooling Asian studies, only BACEI-G allele appeared to increase risk of developing Alzheimer's disease. Through combination-analysis of the data about the A2M-I/D and the A2M-IIe1000Val variants, the A2M gene was suggested to be associated with Alzheimer's disease. (c) 2005 Lippincott Williams & Wilkins.

引用

收藏

页码：1023 / 1026

页数：4

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