No association between 5HT-2A and bipolar disorder irrespective of genomic imprinting

被引：8

作者：

Murphy, VE

Mynett-Johnson, LA ^{[1
]}

Claffey, E

Shields, DC

McKeon, P

机构：

[1] Univ Dublin Trinity Coll, Dept Genet, Dublin 2, Ireland

[2] St Patricks Hosp, Dublin, Ireland

来源：

AMERICAN JOURNAL OF MEDICAL GENETICS | 2001年 / 105卷 / 05期

关键词：

bipolar affective disorder; imprinting; family trios; association; serotonin;

D O I：

10.1002/ajmg.1435.abs

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recent evidence that 5HT-2A may be subjected to genomic imprinting prompted us to examine a collection of Irish family trios (an affected individual and both parents) for evidence of an association between 5HT-2A and bipolar disorder. Family trios offer an advantage over case control studies in regard to genomic imprinting since with family trios it is possible to trace the path of alleles from the parents to the offspring. Using haplotype-based haplotype relative risk (HHRR) and transmission/disequilibrium (TDT) analyses, no evidence was found for an association of 5HT-2A with bipolar affective disorder under the assumption of no imprinting and of imprinting. (C) 2001 Wiley-Liss, Inc.

引用

页码：422 / 425

页数：4

共 22 条

[1] 5-HT2A receptor and bipolar affective disorder: Association studies in affected patients [J].

Arranz, MJ ;

Erdmann, J ;

Kirov, G ;

Rietschel, M ;

Sodhi, M ;

Albus, M ;

Ball, D ;

Maier, W ;

Davies, N ;

Franzek, E ;

Abusaad, I ;

Weigelt, B ;

Murray, R ;

ShimronAbarbanell, D ;

Kerwin, R ;

Propping, P ;

Sham, P ;

Nothen, MM ;

Collier, DA .

NEUROSCIENCE LETTERS, 1997, 224 (02) :95-98

[2] SEROTONIN, SCHIZOPHRENIA AND ANTIPSYCHOTIC DRUG-ACTION [J].

BREIER, A .

SCHIZOPHRENIA RESEARCH, 1995, 14 (03) :187-202

[3] Polymorphic imprinting of the serotonin-2A (5-HT2A) receptor gene in human adult brain [J].

Bunzel, R ;

Blümcke, I ;

Cichon, S ;

Normann, S ;

Schramm, J ;

Propping, P ;

Nöthen, MM .

MOLECULAR BRAIN RESEARCH, 1998, 59 (01) :90-92

[4] 5HT(1A) RECEPTOR GENE AND BIPOLAR AFFECTIVE-DISORDER [J].

GUTIERREZ, B ;

ARRANZ, M ;

FANANAS, L ;

VALLES, V ;

GUILLAMAT, R ;

VANOS, J ;

COLLIER, D .

LANCET, 1995, 346 (8980) :969-969

[5] Genetic variation of the 5-HT2A receptor gene and bipolar affective disorder [J].

Gutierrez, B ;

Bertranpetit, J ;

Collier, D ;

Arranz, MJ ;

Valles, V ;

Guillamat, R ;

VanOs, J ;

Fananas, L .

HUMAN GENETICS, 1997, 100 (5-6) :582-584

[6]

Kato MV, 1996, AM J HUM GENET, V59, P1084

[7]

Kato T, 1996, AM J MED GENET, V67, P546, DOI 10.1002/(SICI)1096-8628(19961122)67:6<546::AID-AJMG6>3.0.CO

[8]

2-F

[9] Evaluating the parent-of-origin effect in bipolar affective disorder - Is a more penetrant subtype transmitted paternally? [J].

Kornberg, JR ;

Brown, JL ;

Sadovnick, AD ;

Remick, RA ;

Keck, PE ;

McElroy, SL ;

Rapaport, MH ;

Thompson, PM ;

Kaul, JB ;

Vrabel, CM ;

Schommer, SC ;

Wilson, T ;

Pizzuco, D ;

Jameson, S ;

Schibuk, L ;

Kelsoe, JR .

JOURNAL OF AFFECTIVE DISORDERS, 2000, 59 (03) :183-192

[10]

Lin JP, 1997, GENET EPIDEMIOL, V14, P665, DOI 10.1002/(SICI)1098-2272(1997)14:6<665::AID-GEPI19>3.0.CO

← 1 2 3 →