Cutting edge: Vasoactive intestinal peptide (VIP) induces differentiation of Th17 cells with a distinctive cytokine profile

被引：44

作者：

Yadav, Mahesh

Rosenbaum, Jennifer

Goetzl, Edward J. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

来源：

JOURNAL OF IMMUNOLOGY | 2008年 / 180卷 / 05期

关键词：

D O I：

10.4049/jimmunol.180.5.2772

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immune cellular effects of vasoactive intestinal peptide (VIP) are transduced by VIP G protein-coupled receptors type 1 (VPAC(1)) and type 2 (VPAC(2)). We now show that VIP with TGF beta stimulates the transformation of CD4 T cells to a distinctive type of Th17 cell that generates IL-17 but not IL-6 or IL- 21. VIP induction of Th17 cells was higher in VPAC(2) knockout mice than wild-type mice, suggesting that VPAC(2) is the principal transducer. Compared with Th17 cells elicited by IL-6, those evoked by VIP were similar in the secretion of IL-17 and IL-22 but lacked IL-21 secretion. Suppression of VIP induction of Th17 cells by protein kinase A inhibitors and enhancement by pharmacologically increased cAMP supports a role for this signal. The ability of VIP-VPAC(1) axis signals to evoke development of a novel type of Th17 cells demonstrates the unique specificity of neuroregulatory mechanisms in the immunological environment.

引用

页码：2772 / 2776

页数：5

共 20 条

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