Enzymatic resolution of 2,2,2-trifluoro-1-(1-pyrenyl)ethanol with lipases

被引：8

作者：

Kato, K

Katayama, M

Fujii, S

Kimoto, H

机构：

[1] Department of Chemistry, National Industrial Research Institute of Nagoya, Nagoya, Hirate-cho, Kita-ku

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1997年 / 61卷 / 01期

关键词：

lipase; enantioselective alcoholysis; enzymatic resolution; CATALYZED OPTICAL RESOLUTION; ACYLATION;

D O I：

10.1271/bbb.61.194

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The optical resolution of (+/-)-2,2,2-trifluoro-1-(1-pyrenyl)ethanol was achieved by using lipases. In particular, Pseudomonas aeruginosa lipase (lipase LIP) showed high enantioselectivity (E = > 100) and reactivity in the alcoholysis of the chloroacetyl ester of the title compound, The reactivity of the lipase LIP-catalyzed enantioselective alcoholysis of the chloroacetate with 1-hexanol was much higher than that of the acetylating the alcohol with vinyl acetate.

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收藏

页码：194 / 196

页数：3

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