RGD modified polymers: biomaterials for stimulated cell adhesion and beyond

被引：2030

作者：

Hersel, U ^{[1
]}

Dahmen, C ^{[1
]}

Kessler, H ^{[1
]}

机构：

[1] Tech Univ Munich, Inst Organ Chem & Biochem, D-85747 Garching, Germany

来源：

BIOMATERIALS | 2003年 / 24卷 / 24期

关键词：

RGD peptide; integrin; polymer modification; cell attachment; cell behavior; review;

D O I：

10.1016/S0142-9612(03)00343-0

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Since RGD peptides (R: arginine; G: glycine; D: aspartic acid) have been found to promote cell adhesion in 1984 (Cell attachment activity of fibronectin can be duplicated by small synthetic fragments of the molecule, Nature 309 (1984) 30), numerous materials have been RGD functionalized for academic studies or medical applications. This review gives an overview of RGD modified polymers, that have been used for cell adhesion, and provides information about technical aspects of RGD immobilization on polymers. The impacts of RGD peptide surface density, spatial arrangement as well as integrin affinity and selectivity on cell responses like adhesion and migration are discussed. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：4385 / 4415

页数：31

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