Self-assembled soft nanofibrils of amphipathic polypeptides and their morphological transformation

被引：23

作者：

Kaneko, T

Higashi, M

Matsusaki, M

Akagi, T

Akashi, M

机构：

[1] Osaka Univ, Dept Appl Chem, Grad Sch Engn, Suita, Osaka 5650871, Japan

[2] Kagoshima Univ, Grad Sch Sci & Engn, Dept Nanostruct & Adv Mat, Kagoshima 8900065, Japan

[3] JST, CREST, Kawaguchi 3320012, Japan

来源：

CHEMISTRY OF MATERIALS | 2005年 / 17卷 / 10期

关键词：

D O I：

10.1021/cm048196f

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A study of the morphological transformation on the self-assembled bio-nanoparticles comprised of biologically occurring polypeptides was presented. A hydrophilic polypeptide backbone was modified by an aromatic amino acid side chain, to show strong hydrophobic and π-stacking interactions. A bacterial-secreted polypeptide poly(γ-glutamic acid) sodium salt (γ-PGA; L-Glu/D-Glu = 40/60) was selected. It was observed that the polymers became soluble in dimethyl sulfoxide (DMSO), dimethylformamide, and chloroform beyond a critical value. The result shows that the amphipathic polypeptide chains with aromatic amino acid pendant groups self-assembled in an appropriate interaction to yield transformable nanofibrils.

引用

页码：2484 / 2486

页数：3

共 11 条

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