Conversion of alcohols to bromides using a fluorous phosphine

被引：19

作者：

Desmaris, L ^{[1
]}

Percina, N ^{[1
]}

Cottier, L ^{[1
]}

Sinou, D ^{[1
]}

机构：

[1] Univ Lyon 1, CNRS, Lab Synth Asymetr, CPE Lyon, F-69622 Villeurbanne, France

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 41期

关键词：

fluorous triphenylphosphine; tetrabromomethane; fluorous solvent; recycling;

D O I：

10.1016/j.tetlet.2003.08.064

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Reaction of alcohols with the fluorous phosphine-carbon tetrabromide complex in toluene or in a two-phase toluene-FC-72 system afforded the corresponding bromides in good yields. The fluorous-phosphine oxide is readily separated by liquid-liquid extraction, providing an alternative to the homogeneous triphenylphosphine-carbon tetrachloride conversion, as well as to the polymer-supported phosphine method. The fluorous phosphine oxide Could be reduced and the product reused. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：7589 / 7591

页数：3

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