Antagonistic Pleiotropy at the Human IL6 Promoter Confers Genetic Resilience to the Pro-Inflammatory Effects of Adverse Social Conditions in Adolescence

被引：34

作者：

Cole, Steven W. ^{[1
]}

Arevalo, Jesusa M. G.

Manu, Kavya

Telzer, Eva H. ^{[3
]}

Kiang, Lisa ^{[4
]}

Bower, Julienne E. ^{[2
,3
]}

Irwin, Michael R.

Fuligni, Andrew J.

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Med,Mol Biol Inst, Norman Cousins Ctr,Jonsson Comprehens Canc Ctr, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Dept Med, Norman Cousins Ctr, Los Angeles, CA 90095 USA

[3] Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA 90095 USA

[4] Wake Forest Univ, Dept Psychol, Winston Salem, NC 27109 USA

来源：

DEVELOPMENTAL PSYCHOLOGY | 2011年 / 47卷 / 04期

关键词：

gene environment interaction; SES; stress; adolescence; inflammation; C-REACTIVE PROTEIN; INTIMA-MEDIA THICKNESS; SOCIOECONOMIC POSITION; CARDIOVASCULAR RISK; PHYSICAL HEALTH; CHRONIC STRESS; CHILDHOOD; INTERLEUKIN-6; TWINS; POLYMORPHISMS;

D O I：

10.1037/a0023871

中图分类号：

B844 [发展心理学（人类心理学）];

学科分类号：

040206 [发展心理学];

摘要：

The authors tested the evolutionary genetic hypothesis that the functional form of an asymmetrically risky Gene X Environment interaction will differ as a function of age-related antagonistic pleiotropy (i.e., show opposite effects in young vs. old individuals). Previous studies have identified a polymorphism in the human IL6 promoter (rs1800795; IL6 - 174 G/C) that interacts with adverse socioenvironmental conditions to promote chronic inflammation in older adults (elevated C-reactive protein). This study identifies a protective effect of the same polymorphism in 17- to 19-year-old adolescents confronting socioeconomic adversity. Over 60% of the environmental risk contribution to the IL6 X Socioeconomic Status interaction could be accounted for by interpersonal stress and adult role burden. Thus, the IL6 - 174G allele does not represent an undifferentiated risk factor but instead sensitizes inflammatory biology to socioenvironmental conditions, conferring either genetic vulnerability or resilience depending on the developmental "somatic environment" that interacts with social conditions to influence gene expression.

引用

页码：1173 / 1180

页数：8

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