Structural basis of potent Zika-dengue virus antibody cross-neutralization

被引：406

作者：

Barba-Spaeth, Giovanna ^{[1
,2
]}

Dejnirattisai, Wanwisa ^{[3
]}

Rouvinski, Alexander ^{[1
,2
]}

Vaney, Marie-Christine ^{[1
,2
]}

Medits, Iris ^{[4
]}

Sharma, Arvind ^{[1
,2
]}

Simon-Loriere, Etienne ^{[5
,6
]}

Sakuntabhai, Anavaj ^{[5
,6
]}

Cao-Lormeau, Van-Mai ^{[7
]}

Haouz, Ahmed ^{[8
,9
]}

England, Patrick ^{[9
,10
]}

Stiasny, Karin ^{[4
]}

Mongkolsapaya, Juthathip ^{[3
,11
]}

Heinz, Franz X. ^{[4
]}

Screaton, Gavin R. ^{[3
]}

Rey, Felix A. ^{[1
,2
]}

机构：

[1] Inst Pasteur, Unite Virol Struct, Dept Virol, F-75724 Paris 15, France

[2] CNRS, UMR Virol 3569, F-75724 Paris 15, France

[3] Imperial Coll London, Dept Med, Div Immunol & Inflammat, Hammersmith Campus, London W12 0NN, England

[4] Med Univ Vienna, Dept Virol, Kinderspitalgasse 15, A-1095 Vienna, Austria

[5] Inst Pasteur, Unite Genet Fonct Malad Infect, Dept Genomes & Genet, F-75724 Paris 15, France

[6] CNRS, URA 3012, F-75724 Paris 15, France

[7] Inst Louis Malarde, Unit Emerging Infect Dis, F-98713 Papeete, Tahiti, France

[8] Inst Pasteur, Plateforme Cristallog CiTech, Dept Biol Struct & Chim, F-75724 Paris 15, France

[9] CNRS, UMR 3528, F-75724 Paris 15, France

[10] Inst Pasteur, Plateforme Biophys Macromol & Leurs Interact, CiTech, Dept Biol Struct & Chim, F-75724 Paris 15, France

[11] Mahidol Univ, Siriraj Hosp, Dengue Hemorrhag Fever Res Unit, Off Res & Dev,Fac Med, Bangkok 10700, Thailand

来源：

NATURE | 2016年 / 536卷 / 7614期

基金：

英国医学研究理事会; 奥地利科学基金会;

关键词：

REACTIVE ANTIBODIES; FUSION-LOOP; IN-VIVO; FLAVIVIRUSES; MATURATION; INFECTION; ENHANCEMENT; RECOGNITION; DYNAMICS; RECEPTOR;

D O I：

10.1038/nature18938

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Zika virus is a member of the Flavivirus genus that had not been associated with severe disease in humans until the recent outbreaks, when it was linked to microcephaly in newborns in Brazil and to Guillain-Barre syndrome in adults in French Polynesia. Zika virus is related to dengue virus, and here we report that a subset of antibodies targeting a conformational epitope isolated from patients with dengue virus also potently neutralize Zika virus. The crystal structure of two of these antibodies in complex with the envelope protein of Zika virus reveals the details of a conserved epitope, which is also the site of interaction of the envelope protein dimer with the precursor membrane (prM) protein during virus maturation. Comparison of the Zika and dengue virus immunocomplexes provides a lead for rational, epitope-focused design of a universal vaccine capable of eliciting potent cross-neutralizing antibodies to protect simultaneously against both Zika and dengue virus infections.

引用

页码：48 / +

页数：19

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