Linking lipids to Alzheimer's disease: cholesterol and beyond

被引：728

作者：

Di Paolo, Gilbert ^{[1
]}

Kim, Tae-Wan ^{[1
]}

机构：

[1] Columbia Univ, Dept Pathol & Cell Biol, Taub Inst Res Alzheimers Dis & Aging Brain, Med Ctr, New York, NY 10032 USA

来源：

NATURE REVIEWS NEUROSCIENCE | 2011年 / 12卷 / 05期

基金：

美国国家卫生研究院;

关键词：

AMYLOID PRECURSOR PROTEIN; GENOME-WIDE ASSOCIATION; A-BETA; GAMMA-SECRETASE; APOLIPOPROTEIN-E; MOUSE MODEL; TAU PHOSPHORYLATION; IDENTIFIES VARIANTS; COGNITIVE DEFICITS; PHOSPHOLIPASE D1;

D O I：

10.1038/nrn3012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Lipid-mediated signalling regulates a plethora of physiological processes, including crucial aspects of brain function. In addition, dysregulation of lipid pathways has been implicated in a growing number of neurodegenerative disorders, such as Alzheimer's disease (AD). Although much attention has been given to the link between cholesterol and AD pathogenesis, growing evidence suggests that other lipids, such as phosphoinositides and phosphatidic acid, have an important role. Regulators of lipid metabolism (for example, statins) are a highly successful class of marketed drugs, and exploration of lipid dysregulation in AD and identification of novel therapeutic agents acting through relevant lipid pathways offers new and effective options for the treatment of this devastating disorder.

引用

页码：284 / 296

页数：13

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