N-acylbenzotriazoles:: Neutral acylating reagents for the preparation of primary, secondary, and tertiary amides

被引：243

作者：

Katritzky, AR ^{[1
]}

He, HY ^{[1
]}

Suzuki, K ^{[1
]}

机构：

[1] Univ Florida, Dept Chem, Ctr Heterocycl Chem, Gainesville, FL 32611 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2000年 / 65卷 / 24期

关键词：

D O I：

10.1021/jo000792f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Readily available N-acylbenzotriazoles 2a-q efficiently acylate aqueous ammonia and primary and secondary amines to give primary, secondary, and tertiary amides in good to excellent yields. The wide applicability of the procedure is illustrated by the preparation of (i) alpha -hydroxyamides from alpha -hydroxy acids and of(ii) perfluoroalkylated amides.

引用

页码：8210 / 8213

页数：4

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