Characterization of single-core magnetite nanoparticles for magnetic imaging by SQUID relaxometry

被引：53

作者：

Adolphi, Natalie L. ^{[1
]}

Huber, Dale L. ^{[2
]}

Bryant, Howard C. ^{[3
]}

Monson, Todd C. ^{[2
]}

Fegan, Danielle L. ^{[3
]}

Lim, JitKang ^{[4
]}

Trujillo, Jason E. ^{[5
]}

Tessier, Trace E. ^{[3
]}

Lovato, Debbie M. ^{[5
]}

Butler, Kimberly S. ^{[5
]}

Provencio, Paula P. ^{[2
]}

Hathaway, Helen J. ^{[6
]}

Majetich, Sara A. ^{[4
]}

Larson, Richard S. ^{[5
]}

Flynn, Edward R. ^{[3
]}

机构：

[1] Univ New Mexico, Dept Biochem & Mol Biol, Albuquerque, NM 87131 USA

[2] Sandia Natl Labs, Albuquerque, NM 87185 USA

[3] Senior Sci LLC, Albuquerque, NM 87111 USA

[4] Carnegie Mellon Univ, Dept Phys, Pittsburgh, PA 15213 USA

[5] Univ New Mexico, Dept Pathol, Canc Res & Treatment Ctr, Albuquerque, NM 87131 USA

[6] Univ New Mexico, Dept Cell Biol & Physiol, Albuquerque, NM 87131 USA

来源：

PHYSICS IN MEDICINE AND BIOLOGY | 2010年 / 55卷 / 19期

基金：

美国国家卫生研究院; 美国国家科学基金会;

关键词：

INTERACTING PARTICLES; MAGNETORELAXOMETRY; SYSTEM; RELAXATION; MECHANISMS; BINDING;

D O I：

10.1088/0031-9155/55/19/023

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Optimizing the sensitivity of SQUID (superconducting quantum interference device) relaxometry for detecting cell-targeted magnetic nanoparticles for in vivo diagnostics requires nanoparticles with a narrow particle size distribution to ensure that the Neel relaxation times fall within the measurement timescale (50 ms-2 s, in this work). To determine the optimum particle size, single-core magnetite nanoparticles (with nominal average diameters 20, 25, 30 and 35 nm) were characterized by SQUID relaxometry, transmission electron microscopy, SQUID susceptometry, dynamic light scattering and zeta potential analysis. The SQUID relaxometry signal (detected magnetic moment/kg) from both the 25 nm and 30 nm particles was an improvement over previously studied multicore particles. However, the detected moments were an order of magnitude lower than predicted based on a simple model that takes into account the measured size distributions (but neglects dipolar interactions and polydispersity of the anisotropy energy density), indicating that improved control of several different nanoparticle properties (size, shape and coating thickness) will be required to achieve the highest detection sensitivity. Antibody conjugation and cell incubation experiments show that single-core particles enable a higher detected moment per cell, but also demonstrate the need for improved surface treatments to mitigate aggregation and improve specificity.

引用

页码：5985 / 6003

页数：19

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