Phenothiazinium-based photosensitizers: antibacterials of the future?

被引：35

作者：

Phoenix, DA ^{[1
]}

Harris, F

机构：

[1] Univ Cent Lancashire, Fac Sci, Deans Off, Preston PR1 2HE, Lancs, England

[2] Univ Cent Lancashire, Dept Forens & Invest Sci, Preston PR1 2HE, Lancs, England

来源：

TRENDS IN MOLECULAR MEDICINE | 2003年 / 9卷 / 07期

关键词：

D O I：

10.1016/S1471-4914(03)00115-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Phenothiazinium-based molecules exhibit phototoxicity against a broad range of bacteria. In general, these photosensitizers use several cellular uptake pathways, coupled to type II mechanisms of photo-oxidation, to inflict bacterial damage. These molecules show potential to act as novel alternatives to conventional antibiotics.

引用

页码：283 / 285

页数：3

共 21 条

[1] A study of the uptake of toluidine blue O by Porphyromonas gingivalis and the mechanism of lethal photosensitization [J].

Bhatti, M ;

MacRobert, A ;

Meghji, S ;

Henderson, B ;

Wilson, M .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1998, 68 (03) :370-376

[2]

HARRIS F, IN PRESS J EUR CIT Q

[3] Mechanism of guanine-specific DNA damage by oxidative stress and its role in carcinogenesis and aging [J].

Kawanishi, S ;

Hiraku, Y ;

Oikawa, S .

MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH, 2001, 488 (01) :65-76

[4]

Komerik N, 2000, PHOTOCHEM PHOTOBIOL, V72, P676, DOI 10.1562/0031-8655(2000)072<0676:TEOPAO>2.0.CO

[5]

[6]

Phoenix DA, 2003, J E C QUA L, V1, P44

[7] Singlet oxygen induces oxidation of cellular DNA [J].

Ravanat, JL ;

Di Mascio, P ;

Martinez, GR ;

Medeiros, MHG ;

Cadet, J .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (51) :40601-40604

[8] Single cell gel electrophoresis assay: methodology and applications [J].

Rojas, E ;

Lopez, MC ;

Valverde, M .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 1999, 722 (1-2) :225-254

[9] Antibiotic-resistant enterococci: the mechanisms and dynamics of drug introduction and resistance [J].

Shepard, BD ;

Gilmore, MS .

MICROBES AND INFECTION, 2002, 4 (02) :215-224

[10] Methylene blue derivatives - suitable photoantimicrobials for blood product disinfection? [J].

Wainwright, M .

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 2000, 16 (04) :381-394

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