Whole-genome views of chromatin structure

被引：23

作者：

Lodén, M ^{[1
]}

van Steensel, B ^{[1
]}

机构：

[1] Netherlands Canc Inst, NL-1066 CX Amsterdam, Netherlands

来源：

CHROMOSOME RESEARCH | 2005年 / 13卷 / 03期

关键词：

chromatin; DNA microarray; histone; nuclear organization; nucleosome;

D O I：

10.1007/s10577-005-2166-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA in eukaryotes is packed into chromatin. The basic component of chromatin is the nucleosome consisting of DNA wrapped around a histone octamer. Inside the cell nucleus, chromatin is folded into higher-order structures through various mechanisms, including repositioning of nucleosomes along the DNA, packing of nucleosomes into more condensed 3-dimensional configurations, looping of chromatin fibres, and tethering of chromosomal regions to nuclear structures. Over the past few years, new microarray-based methods have been developed for the genome-wide mapping of various aspects of chromatin structure. These methods are beginning to provide insights into the different types of chromatin and the architectural principles that govern the 3-dimensional organisation of the genome inside the nucleus.

引用

页码：289 / 298

页数：10

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