Whole-genome views of chromatin structure

被引：23

作者：

Lodén, M ^{[1
]}

van Steensel, B ^{[1
]}

机构：

[1] Netherlands Canc Inst, NL-1066 CX Amsterdam, Netherlands

来源：

CHROMOSOME RESEARCH | 2005年 / 13卷 / 03期

关键词：

chromatin; DNA microarray; histone; nuclear organization; nucleosome;

D O I：

10.1007/s10577-005-2166-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DNA in eukaryotes is packed into chromatin. The basic component of chromatin is the nucleosome consisting of DNA wrapped around a histone octamer. Inside the cell nucleus, chromatin is folded into higher-order structures through various mechanisms, including repositioning of nucleosomes along the DNA, packing of nucleosomes into more condensed 3-dimensional configurations, looping of chromatin fibres, and tethering of chromosomal regions to nuclear structures. Over the past few years, new microarray-based methods have been developed for the genome-wide mapping of various aspects of chromatin structure. These methods are beginning to provide insights into the different types of chromatin and the architectural principles that govern the 3-dimensional organisation of the genome inside the nucleus.

引用

页码：289 / 298

页数：10

共 58 条

[31] A methyltransferase targeting assay reveals silencer-telomere interactions in budding yeast [J].

Lebrun, E ;

Fourel, GV ;

Defossez, PA ;

Gilson, E .

MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (05) :1498-1508

[32] Evidence for nucleosome depletion at active regulatory regions genome-wide [J].

Lee, CK ;

Shibata, Y ;

Rao, B ;

Strahl, BD ;

Lieb, JD .

NATURE GENETICS, 2004, 36 (08) :900-905

[33] Cohesin relocation from sites of chromosomal loading to places of convergent transcription [J].

Lengronne, A ;

Katou, Y ;

Mori, S ;

Yokobayashi, S ;

Kelly, GP ;

Itoh, T ;

Watanabe, Y ;

Shirahige, K ;

Uhlmann, F .

NATURE, 2004, 430 (6999) :573-578

[34] Promoter-specific binding of Rap1 revealed by genome-wide maps of protein-DNA association [J].

Lieb, JD ;

Liu, XL ;

Botstein, D ;

Brown, PO .

NATURE GENETICS, 2001, 28 (04) :327-334

[35] Role of transposable elements in heterochromatin and epigenetic control [J].

Lippman, Z ;

Gendrel, AV ;

Black, M ;

Vaughn, MW ;

Dedhia, N ;

McCombie, WR ;

Lavine, K ;

Mittal, V ;

May, B ;

Kasschau, KD ;

Carrington, JC ;

Doerge, RW ;

Colot, V ;

Martienssen, R .

NATURE, 2004, 430 (6998) :471-476

[36] HP1 and the dynamics of heterochromatin maintenance [J].

Maison, C ;

Almouzni, G .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2004, 5 (04) :296-304

[37] Coordinated methyl and RNA binding is required for heterochromatin localization of mammalian HP1α [J].

Muchardt, C ;

Guillemé, M ;

Seeler, JS ;

Trouche, D ;

Dejean, A ;

Yaniv, M .

EMBO REPORTS, 2002, 3 (10) :975-981

[38]

Oberley MJ, 2004, METHOD ENZYMOL, V376, P315

[39]

Pirrotta V, 1999, BBA-REV CANCER, V1424, pM1

[40] Histories are first hyperacetylated and then lose contact with the activated PHO5 promoter [J].

Reinke, H ;

Hörz, W .

MOLECULAR CELL, 2003, 11 (06) :1599-1607

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