Targeting Epithelial-Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer

被引：643

作者：

Du, Bowen ^{[1
]}

Shim, Joong Sup ^{[1
]}

机构：

[1] Univ Macau, Fac Hlth Sci, Ave Univ, Taipa 999078, Macau Sar, Peoples R China

来源：

MOLECULES | 2016年 / 21卷 / 07期

关键词：

epithelial-mesenchymal transition; drug resistance; chemotherapy; cancer stem cells; E-CADHERIN EXPRESSION; GROWTH-FACTOR-BETA; BREAST-CANCER; MULTIDRUG-RESISTANCE; STEM-CELLS; DOWN-REGULATION; MIR-200; FAMILY; DOXORUBICIN RESISTANCE; HEDGEHOG PATHWAY; UP-REGULATION;

D O I：

10.3390/molecules21070965

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Epithelial-mesenchymal transition (EMT) is known to play an important role in cancer progression, metastasis and drug resistance. Although there are controversies surrounding the causal relationship between EMT and cancer metastasis, the role of EMT in cancer drug resistance has been increasingly recognized. Numerous EMT-related signaling pathways are involved in drug resistance in cancer cells. Cells undergoing EMT show a feature similar to cancer stem cells (CSCs), such as an increase in drug efflux pumps and anti-apoptotic effects. Therefore, targeting EMT has been considered a novel opportunity to overcome cancer drug resistance. This review describes the mechanism by which EMT contributes to drug resistance in cancer cells and summarizes new advances in research in EMT-associated drug resistance.

引用

页数：15

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