FLASH, a component of the FAS-CAPSASE8 apoptotic pathway, is directly regulated by Hoxb4 in the notochord

被引：16

作者：

Morgan, R ^{[1
]}

Nalliah, A ^{[1
]}

El-Kadi, ASM ^{[1
]}

机构：

[1] St George Hosp, Sch Med, Dept Anat & Dev Biol, London SW17 0RE, England

来源：

DEVELOPMENTAL BIOLOGY | 2004年 / 265卷 / 01期

关键词：

Hox; Hoxb4; notochord; FLASH; apoptosis; Xenopus;

D O I：

10.1016/j.ydbio.2003.09.030

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The Hox genes are a family of homeodomain-containing transcription factors that confer positional identity during development. Although their regulation and function have been extensively studied, very little is known of their downstream target genes. Here we show that Hoxb4 directly induces the expression of FLASH in the notochord of embryos after neurulation. FLASH is a component of the FAS-CAPSASE8 apoptotic pathway, and blocking its activity, or that of HoxN, prevents apoptosis in the notochord. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：105 / 112

页数：8

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