Enamide synthesis by copper-catalyzed cross-coupling of amides and potassium alkenyltrifluoroborate salts

被引：128

作者：

Bolshan, Yuri ^{[1
]}

Batey, Robert A. ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 11期

关键词：

copper; cross-coupling; enamides; homogeneous catalysis;

D O I：

10.1002/anie.200704711

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A new partner: Potassium alkenyltrifluoroborate salts undergo coupling with amides to give enamides in the presence of a Cu(OAc)2 catalyst and under mild oxidative conditions (see scheme). The air- and water-stable alkenyltrifluoroborate salts offer a convenient alternative to alkenyl halides as cross-coupling partners. A range of amides undergo coupling including cyclic amides, imides, and carbamates as well as benzamides. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2109 / 2112

页数：4

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