Biodegradable microcapsules designed via 'click' chemistry

被引：90

作者：

De Geest, Bruno G. ^{[1
,2
]}

Van Camp, Wim ^{[3
]}

Du Prez, Filip E. ^{[3
]}

De Smedt, Stefaan C. ^{[2
]}

Demeester, Jo ^{[2
]}

Hennink, Wim E. ^{[1
]}

机构：

[1] Univ Utrecht, Dept Pharmaceut Sci, NL-3584 CA Utrecht, Netherlands

[2] Univ Ghent, Lab Gen Biochem & Phys Pharm, B-9000 Ghent, Belgium

[3] Univ Ghent, Dept Organ Chem, Polymer Chem Res Grp, B-9000 Ghent, Belgium

来源：

CHEMICAL COMMUNICATIONS | 2008年 / 02期

关键词：

D O I：

10.1039/b714199h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Dextrans modified with alkyne and azide groups through hydrolysable carbonate esters form degradable microcapsules after Cu(I) catalysed 'click' reaction between azides and alkynes yielding triazole cross-links.

引用

页码：190 / 192

页数：3

共 15 条

[1] Self-rupturing microcapsules [J].

De Geest, BG ;

Déjugnat, C ;

Sukhorukov, GB ;

Braeckmans, K ;

De Smedt, SC ;

Demeester, J .

ADVANCED MATERIALS, 2005, 17 (19) :2357-+

[2] Intracellularly degradable polyelectrolyte microcapsules [J].

De Geest, BG ;

Vandenbroucke, RE ;

Guenther, AM ;

Sukhorukov, GB ;

Hennink, WE ;

Sanders, NN ;

Demeester, J ;

De Smedt, SC .

ADVANCED MATERIALS, 2006, 18 (08) :1005-+

[3]

De Geest BG, 2007, CHEM SOC REV, V36, P636, DOI 10.1039/b600460c

[4] The convergence of synthetic organic and polymer chemistries [J].

Hawker, CJ ;

Wooley, KL .

SCIENCE, 2005, 309 (5738) :1200-1205

[5]

Kolb HC, 2001, ANGEW CHEM INT EDIT, V40, P2004, DOI 10.1002/1521-3773(20010601)40:11<2004::AID-ANIE2004>3.0.CO

[6]

2-5

[7] Designing materials for biology and medicine [J].

Langer, R ;

Tirrell, DA .

NATURE, 2004, 428 (6982) :487-492

[8] 1,3-dipolar cycloadditions of azides and alkynes: A universal ligation tool in polymer and materials science [J].

Lutz, Jean-Francois .

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2007, 46 (07) :1018-1025

[9] Synthesis of well-defined hydrogel networks using Click chemistry [J].

Malkoch, Michael ;

Vestberg, Robert ;

Gupta, Nalini ;

Mespouille, Laetitia ;

Dubois, Philipe ;

Mason, Andrew F. ;

Hedrick, James L. ;

Liao, Qi ;

Frank, Curtis W. ;

Kingsbury, Kevin ;

Hawker, Craig J. .

CHEMICAL COMMUNICATIONS, 2006, (26) :2774-2776

[10] Biodegradable nanogels prepared by atom transfer radical polymerization as potential drug delivery carriers: Synthesis, biodegradation, in vitro release, and bioconjugation [J].

Oh, Jung Kwon ;

Siegwart, Daniel J. ;

Lee, Hyung-il ;

Sherwood, Gizelle ;

Peteanu, Linda ;

Hollinger, Jeffrey O. ;

Kataoka, Kazunori ;

Matyjaszewski, Krzysztof .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (18) :5939-5945

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