A single-step polymerization method for poly(β-amino ester) biodegradable hydrogels

被引：24

作者：

Biswal, Dipti ^{[1
]}

Wattamwar, Paritosh R. ^{[1
]}

Dziubla, Thomas D. ^{[1
]}

Hilt, J. Zach ^{[1
]}

机构：

[1] Univ Kentucky, Lexington, KY 40506 USA

来源：

POLYMER | 2011年 / 52卷 / 26期

关键词：

Hydrogel; Poly(beta-amino ester); Swelling; TUMOR-TARGETED DELIVERY; PH-SENSITIVE SYSTEM; GENE DELIVERY; NETWORK PROPERTIES; PARALLEL SYNTHESIS; HYDROPHOBIC DRUGS; NANOPARTICLES; LIBRARY; TRANSFECTION;

D O I：

10.1016/j.polymer.2011.10.058

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 [高分子化学与物理];

摘要：

A novel one-step method for the preparation of poly(beta-amino ester) hydrogels has been developed. The one-step method utilizes a Michael type addition reaction between a difunctional diacrylate and a tetrafunctional primary diamine to create a crosslinked biodegradable hydrogel. It was shown that the molar ratio of the reactive acrylate to amine controlled the extent of polymerization and crosslinking density of the hydrogel system, which enabled for the end properties of the network (e.g., swelling, degradation, and mechanical) to be tuned. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：5985 / 5992

页数：8

共 31 条

[1]

Parallel synthesis and biophysical characterization of a degradable polymer library for gene delivery [J].